Lomotil poisoning in children
| Autor: | J A Curtis, K M Goel |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.drug_class medicine.medical_treatment Isonipecotic Acids Naloxone Antidiarrhoeal medicine Humans Child Gastric Lavage Depression (differential diagnoses) Coma Diphenoxylate Dose-Response Relationship Drug business.industry Narcotic antagonist Stomach digestive oral and skin physiology Infant Gastric lavage medicine.anatomical_structure Child Preschool Anesthesia Pediatrics Perinatology and Child Health Female medicine.symptom Respiratory Insufficiency business Research Article medicine.drug |
| Zdroj: | Archives of Disease in Childhood. 54:222-225 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/adc.54.3.222 |
| Popis: | 45 children were admitted to hospital after ingesting varying quantities of diphenoxylate (Lomotil). One died and 44 recovered without any sequelae. Four patients were comatose, 32 were drowsy, and 9 suffered respiratory depression. No correlation was found between ingested dose and the severity of symptoms. Because of its action in rendering the gut atonic, removal of diphenoxylate by gastric lavage is mandatory, even in patients admitted at least 24 hours after drug ingestion. Naloxone is the narcotic antagonist of choice, and should be used in all cases where suspected diphenoxylate poisoning leads to respiratory depression or coma. The use of Lomotil as an antidiarrhoeal agent in children is difficult to justify. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|