Gene expression profiling in chronic inflammatory demyelinating polyneuropathy
| Autor: | Louis H. Weimer, Marcelo R. Olarte, Norman Latov, Marinos C. Dalakas, Zhaoying Xiang, Thomas H. Brannagan, Mark A. Edgar, Susanne Renaud, Arthur P. Hays, Howard W. Sander, Moris J. Danon |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Immunology Chronic inflammatory demyelinating polyneuropathy Sural nerve Biology Polyneuropathies Sural Nerve TAC1 Gene expression medicine Immunology and Allergy Humans Remyelination education Aged Oligonucleotide Array Sequence Analysis education.field_of_study Nerve biopsy medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Middle Aged medicine.disease Up-Regulation Gene expression profiling medicine.anatomical_structure Neurology Chronic Disease Allograft inflammatory factor 1 Female Neurology (clinical) Demyelinating Diseases Signal Transduction |
| Zdroj: | Journal of neuroimmunology. 159(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis. |
| Databáze: | OpenAIRE |
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