Rufinamide in children and adults in routine clinical practice
| Autor: | Albert Molins, P. Fossas, Juan-Luis Becerra, Sònia Jaraba, A. Cano, Manuel Toledo, J. Burcet, S. Fernández, Júlia Miró, Estevo Santamarina, G. Pico, E. Miravet, Mercè Falip, Miquel Raspall |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
focal epilepsy
Adult Male Pediatrics medicine.medical_specialty adulthood Resistant epilepsy Adolescent rufinamide Nausea Vomiting Rufinamide 03 medical and health sciences Epilepsy 0302 clinical medicine Refractory Seizures Weight Loss medicine Humans 030212 general & internal medicine generalized epilepsy Child Atonic seizure childhood business.industry Lennox Gastaut Syndrome General Medicine Middle Aged Triazoles medicine.disease Neurology Anesthesia Concomitant Anticonvulsants Epilepsy Generalized Female Neurology (clinical) Levetiracetam medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
| ISSN: | 1600-0404 0001-6314 |
| Popis: | Objective To explore the long-term effectiveness of rufinamide in managing Lennox–Gastaut Syndrome (LGS), other epileptic encephalopathies, and intractable focal epilepsies in adults and children in routine clinical practice. Methods A multicentre, retrospective chart review of patients prescribed adjunctive rufinamide at seven Spanish epilepsy centres, with assessments at six and 12 months. Results We evaluated data from 58 patients (40 male, age range 7–57 years), 25 of whom were diagnosed with LGS, 12 with other epileptic encephalopathies and 21 of whom were diagnosed with focal epilepsies, mainly frontal lobe. The mean daily rufinamide dose was 32.0 mg/kg (range 12.5–66.7 mg/kg) in children and 24.7 mg/kg (range 5.0–47.0 mg/kg) in adults, and the most commonly used concomitant antiepileptic drugs were levetiracetam and valproate. Rufinamide was discontinued in 25 patients (43.1%) during the 1-year follow-up, and the most common reason was lack of effectiveness (n = 12, 20.7% of total). The frequency of generalized tonic–clonic seizures was significantly reduced from baseline at 6 and 12 months (P = 0.001), both in patients with generalized epilepsies and in patients with focal epilepsies. Significant seizure frequency reduction from baseline was observed at 12 months (P = 0.01) for tonic/atonic seizures and at 6 months (P = 0.001) for focal seizures. Side effects were reported in 21 patients (36.2%): nausea, vomiting and weight loss were most frequent. Conclusions Rufinamide was well tolerated and was effective in reducing frequency of generalized tonic–clonic, tonic/atonic and focal seizures in both children and adults with severe refractory epilepsies, primarily LGS. |
| Databáze: | OpenAIRE |
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