Functional lateralization of human gustatory cortex related to handedness disclosed by fMRI study
| Autor: | Denis LeBihan, B. Cerf, Annick Faurion, P. Mac Leod, P. F. Van De Moortele |
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| Přispěvatelé: | Le Bihan, Denis, Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), Danone Research, Groupe DANONE, Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Adult
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging Stimulation Functional Laterality General Biochemistry Genetics and Molecular Biology Lateralization of brain function MESH: Magnetic Resonance Imaging History and Philosophy of Science medicine Animals Humans MESH: Animals MESH: Functional Laterality Cerebral Cortex MESH: Humans medicine.diagnostic_test General Neuroscience MESH: Adult MESH: Cerebrovascular Circulation Anatomy Functional lateralization Magnetic Resonance Imaging MESH: Cerebral Cortex Electrophysiology [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging Cerebrovascular Circulation Taste Coronal plane MESH: Taste Gustatory cortex Psychology Functional magnetic resonance imaging Neuroscience Insula |
| Zdroj: | Annals of the New York Academy of Sciences Annals of the New York Academy of Sciences, Wiley, 1998, 855, pp.575-8 Annals of the New York Academy of Sciences, 1998, 855, pp.575-8 Scopus-Elsevier |
| ISSN: | 0077-8923 1749-6632 |
| Popis: | International audience; Ten healthy subjects aged 20-25 including five right-handed and five left-handed according to the Dellatolas test participated in this functional magnetic resonance imaging (fMRI) study. A 3 Tesla whole-body MR scanner allowed echo planar imaging (EPI)-64 x 64 pixels, repetition time (TR) = 6 s, field of view (FOV) = 20 x 20 cm2--associated to acute anatomical localization of activated foci (256 x 256 pixels). Subjects were bilaterally stimulated with NaCl 85 mM, aspartame 2 mM, quinine hydrochloride 1 mM, glycyrrhizic acid 0.5 mM, guanosine monophosphate 1 mM and D-threonine 250 mM alternating with water. Stimuli and rinse were continuously pushed as bolus of 50 microliters every 3 s to the subject's mouth through microsyringes. We detected brain activated areas by correlation of the MR signal to an on-line perception profile recorded for each experiment and each subject with the finger-span method. We found most activations in the insula and the perisylvian region in agreement with previous electrophysiological studies on monkeys and clinical reports in humans. The superior part of the insula was bilaterally activated, in accordance with a whole-mouth stimulation. A striking lateralization related to handedness was found in a lower part of the insula. This projection in the dominant hemisphere, located in the same coronal plane as the upper insular activation, is the first evidence of a functional lateralization of brain processing involved in taste perception. |
| Databáze: | OpenAIRE |
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