Morphofunctional Changes of Rat Pancreas Under Conditions оf Nitric Oxyde Excess
| Autor: | A.I. Rudenko, V.A. Makarchuk, B.F. Schevchenko, A.M. Babiy, A.A. Galinsky, N.Yu. Oshmyanska |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Intraperitoneal injection RC799-869 Nitric oxide chronic pancreatitis chemistry.chemical_compound Hydroxyproline Blood serum nitric oxide Fibrosis Internal medicine medicine ОКСИД АЗОТА НИТРОПРУССИД НАТРИЯ ХРОНИЧЕСКИЙ ПАНКРЕАТИТ ФИБРОЗ sodium nitroprusside business.industry fibrosis Diseases of the digestive system. Gastroenterology medicine.disease Endocrinology medicine.anatomical_structure chemistry Pancreatitis Sodium nitroprusside Pancreas business medicine.drug |
| Zdroj: | Gastroenterologìa, Vol 47, Iss 4.50, Pp 83-88 (2013) |
| ISSN: | 2518-7880 2308-2097 |
| Popis: | The study was carried out on 40 male Wistar rats after daily intraperitoneal injection of donator of nitric oxide (NO) molecules sodium nitroprusside in a dose of 1.5 mg/kg in 1 day 1 (n = 6); 2 days (n = 6); 6 days (n = 6); 12 days (n = 6); 30 days (n = 6). It is established that an excessive NO intake leads to morphological changes in the pancreas: vasodilation with stasis of blood cells after 1 and 2 days, focal necrosis, destruction of acinar tissue, ductal dilatation with worsening outflow of pancreatic secretion after 6 days; fatty degeneration, segmental apoptosis in 12 days; compensated microcirculatory changes in the body, the formation of fibrous tissue in periductal and perivasal areas with penetration in the interlobular space in 30 days. In the blood serum we detected impaired exocrine pancreatic function: increased activity of pancreatic enzymes — α-amylase and trypsin up to 6 days, and in 30 days — they significantly reduced; increasing the levels of biochemical markers of fibrosis (protein-bound hydroxyproline and hexosamine); failure of endocrine function — increase of glucose level, that is, changes typical for chronic experimental pancreatitis. |
| Databáze: | OpenAIRE |
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