Characterization of Neonatal Infections by Gram-Negative Bacilli and Associated Risk Factors, Havana, Cuba
| Autor: | Yenisel Carmona, Roberto Álvarez, Elizabeth de La C López, Arlenis Oliva, Nobumichi Kobayashi, Meiji Soe Aung, Dianelys Quiñones |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bacilli gram-negative bacilli Fosfomycin Article 03 medical and health sciences 0302 clinical medicine Antibiotic resistance 030225 pediatrics Internal medicine medicine neonatal infection 030212 general & internal medicine antimicrobial resistance biology business.industry Cuba lcsh:Other systems of medicine biology.organism_classification lcsh:RZ201-999 Ciprofloxacin Neonatal infection Infectious Diseases Amikacin Colistin Gentamicin business medicine.drug |
| Zdroj: | Infectious Disease Reports Volume 13 Issue 1 Pages 25-229 Infectious Disease Reports, Vol 13, Iss 25, Pp 219-229 (2021) |
| ISSN: | 2036-7449 |
| DOI: | 10.3390/idr13010025 |
| Popis: | Infections represent an important problem in neonates because of the high mortality. An increase in neonatal infections has been found in Cuban hospitals in recent years. The aim of this study was to provide evidence on the clinical and microbiological behavior of Gram-negative bacilli that cause neonatal infections in hospitals of Havana, Cuba. It was carried out as a descriptive cross-sectional investigation from September 2017 to July 2018 in The Tropical Medicine Institute “Pedro Kouri” (IPK). Sixty-one Gram-negative bacilli isolated from neonates with infections in six Gyneco-Obstetric and Pediatric Hospitals of Havana were analyzed for their species and antimicrobial susceptibility. Late-onset infections were more common than early-onset ones and included urinary tract infection in the community (87%) and sepsis in hospitals (63.3%). Catheter use (47%) and prolonged stay (38%) were the most frequent risk factors. Species of major pathogens were Escherichia coli (47%) and Klebsiella spp. (26%). The isolated Gram-negative bacilli showed high resistance rates to third-generation cephalosporins, ciprofloxacin and gentamicin, while being more susceptible to carbapenems, fosfomycin, colistin and amikacin. The present study revealed the clinical impact of Gram-negative bacilli in neonatology units in hospitals of Havana. Evaluation of antimicrobial susceptibilities to the isolates from neonates is necessary for selection of appropriate empirical therapy and promotion of the rational antibiotic use. |
| Databáze: | OpenAIRE |
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