Long-chain fatty acids and short-chain fatty acids in exhaled breath condensate of patients with chronic obstructive pulmonary disease
| Autor: | I N Gaimolenko, M V Maksimenya, A A Parshina, T A Medvedeva, T M Karavaeva, P P Tereshkov |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Chromatography Fatty Acids food and beverages Fatty acid Pulmonary disease General Medicine Fatty Acids Volatile General Biochemistry Genetics and Molecular Biology Pulmonary Disease Chronic Obstructive 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Volatile fatty acids 030228 respiratory system chemistry Humans lipids (amino acids peptides and proteins) Exhaled breath condensate In patient Long chain fatty acid Long chain |
| Zdroj: | Biomeditsinskaya Khimiya. 67:169-174 |
| ISSN: | 2310-6905 2310-6972 |
| Popis: | In present study we performed gas-liquid chromatographic analysis of exhaled breath condensate to measure volatile fatty acids (C2 - acetic, C3 - propionic, C4 - butanoic, isoC4 - isobutyric, C5 - valerianic, C6 - caproic, C7 - heptanoic) and fatty acid with a long aliphatic chain (C14:0 - myristic, C15:0 - pentadecanoic, C16:0 - palmitic, C16:1 - palmitooleic, C17:0 - heptadecanoic, C17:1 - heptadecenoic, C18:0 - stearic, C18:1 - oleic, C18:2 - linolenic, C18:3ω3 - α-linolenic, C20:4ω6 - arachidonic) in patients suffering from moderate chronic obstructive pulmonary disease (2nd stage, GOLD). We revealed the increase of the total amount of short chain fatty acids (C2, C3, C4, C5) and polyunsaturated (C18:2, C20:4ω6) fatty acids, meanwhile the level of saturated fatty acids (C16:0, C17:0, C18:0) decreased.V ékspirate patsientov s khronicheskoĭ obstruktivnoĭ bolezn'iu legkikh (KhOBL) metodom gazozhidkostnoĭ khromatografii byli opredeleny moliarnye kotsentratsii zhirnykh kislot s korotkoĭ uglevodorodnoĭ tsep'iu (S2 — uksusnoĭ, S3 — propionovoĭ, S4 — maslianoĭ, isoS4 — izomaslianoĭ, S5 — valerianovoĭ, S6 — kapronovoĭ, S7 — geptanovoĭ), protsentnoe soderzhanie vysshikh zhirnykh kislot (S14:0 — miristinovoĭ, S15:0 — pentadekanovoĭ, C16:0 — pal'mitinovoĭ, S16:1 — pal'mitooleinovoĭ, S17:0 — geptadekanovoĭ, S17:1 — geptadetsenovoĭ, S18:0 — stearinovoĭ, C18:1 — oleinovoĭ, S18:2 — linolevoĭ, S18:3ω3 — α-linolenovoĭ, S20:4ω6 — arakhidonovoĭ). U bol'nykh KhOBL so stabil'nym srednetiazhelom techeniem zabolevaniia v ékspirate uvelichivaetsia summarnaia kontsentratsiia zhirnykh kislot s korotkoĭ uglevodorodnoĭ tsep'iu (S2, S3, S4, S5), snizhaetsia dolia nasyshchennykh vysshikh zhirnykh kislot (S16:0, S17:0, S18:0) i uvelichivaetsia soderzhanie polinenasyshchennykh kislot (S18:2, S20:4ω6). Poluchennye dannye mogut byt' ispol'zovany dlia poiska novykh rannikh diagnosticheskikh markerov razvitiia KhOBL i sposobov terapevticheskoĭ korrektsii étogo zabolevaniia. |
| Databáze: | OpenAIRE |
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