In vitro leukocyte response of three-spined sticklebacks (Gasterosteus aculeatus) to helminth parasite antigens
| Autor: | Joseph Lange, Joachim Kurtz, Martin Kalbe, Anna K. Rahn, Frederik Franke, Carlos Fernández, Jörn P. Scharsack, Noémie I. Erin, Jennifer K. Rieger, Irene E. Samonte-Padilla, Theo C. M. Bakker, Janine Dittmar, Miguel Hermida, Thorsten B. H. Reusch, Per Johan Jakobsen, David Haase |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Sympatry
Neutrophils Population Zoology Gasterosteus Trematode Infections Aquatic Science Generalist and specialist species Host-Parasite Interactions Fish Diseases Environmental Chemistry Animals Ligula intestinalis education Respiratory Burst education.field_of_study biology Intermediate host Stickleback General Medicine biology.organism_classification Flow Cytometry Smegmamorpha Immunology Schistocephalus solidus Trematoda |
| Zdroj: | Fishshellfish immunology. 36(1) |
| ISSN: | 1095-9947 |
| Popis: | Highlights: • We investigated in vitro responses of stickleback leukocytes to parasite antigens. • In vitro responses decreased from generalist to specialist parasites. • Responses decreased from Gasterosteusaculeatus not infecting to infecting parasites. • Leukocyte response was increased with parasite prevalence in the natural habitat. • Immunogenicity of antigens was increased with parasite prevalence as well. Helminth parasites of teleost fish have evolved strategies to evade and manipulate the immune responses of their hosts. Responsiveness of fish host immunity to helminth antigens may therefore vary depending on the degree of host-parasite counter-adaptation. Generalist parasites, infective for a number of host species, might be unable to adapt optimally to the immune system of a certain host species, while specialist parasites might display high levels of adaptation to a particular host species. The degree of adaptations may further differ between sympatric and allopatric host-parasite combinations. Here, we test these hypotheses by in vitro exposure of head kidney leukocytes from three-spined sticklebacks (Gasterosteus aculeatus) to antigens from parasites with a broad fish host range (Diplostomum pseudospathaceum, Triaenophorus nodulosus), a specific fish parasite of cyprinids (Ligula intestinalis) and parasites highly specific only to a single fish species as second intermediate host (Schistocephalus pungitii, which does not infect G. aculeatus, and Schistocephalus solidus, infecting G. aculeatus). In vitro responses of stickleback leukocytes to S. solidus antigens from six European populations, with S. solidus prevalence from |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect