Does selective inhibition training reduce relapse rates when added to standard treatment of alcohol use disorder? A randomized controlled trial

Autor: Edwin J. Schenkel, Robert Schöneck, Reinout W. Wiers, Harm Veling, Eni S. Becker, Johannes Lindenmeyer, Mike Rinck
Rok vydání: 2023
Předmět:
Zdroj: Alcoholism-Clinical and Experimental Research, 47, 5, pp. 963-974
Alcoholism: Clinical and Experimental Research 47 (2023) 5
Alcoholism-Clinical and Experimental Research, 47, 963-974
Alcoholism: Clinical and Experimental Research
ISSN: 0145-6008
Popis: Contains fulltext : 290472.pdf (Publisher’s version ) (Open Access) Background: Alcohol-dependent individuals tend to selectively approach alcohol cues in the environment, demonstrating an alcohol approach bias. Approach Bias Modification (ApBM) training can reduce the approach bias and decrease relapse rates in alcohol-dependent patients when added to abstinence-focused treatment. It has therefore become part of regular treatment. Moreover, in Selective Inhibition (SI-) Training, responses to one category of stimuli (i.e., alcohol stimuli) are selectively inhibited in an adapted Go/No-Go-Task. SI-Training has been found to effectively devalue the inhibited category, and to reduce consumption of alcohol in social drinkers. This study investigated whether SI-Training can further improve treatment effects of treatment-as-usual that includes ApBM, and if so, whether the effect is mediated by a devaluation of the inhibited alcohol stimuli. Methods: For 6 sessions, 434 abstinent alcohol-dependent inpatients were randomly assigned to receive either active (n = 214, 32% female) or sham (n= 220, 38% female) SI-Training, in addition to standard treatment including active ApBM. Ratings were used to assess changes in the evaluation of alcohol stimuli after the training. Relapse rates were assessed three months and twelve months after treatment discharge. Results: Alcohol stimuli were rated negatively before and after the training, and the training did not influence these ratings. Evaluation of nonalcoholic drinks became more positive after active SI-Training. Both ApBM and SI-Training showed the expected training effects on reaction times. Contrary to expectations, SI-Training conditions did not yield different abstinence rates three or twelve months after treatment. Conclusions: No evidence was found for the hypothesis that SI-Training would amplify the relapse-preventing effect of ApBM. Moreover, alcohol stimuli were rated negatively before and after treatment and were not influenced by SI-Training. 12 p.
Databáze: OpenAIRE