Focusing on Asthma and Chronic Obstructive Pulmonary Disease with COVID-19
| Autor: | Mert Ahmet Kuşkucu, Ahmet Dirican, Sermin Borekci, Ridvan Karaali, Sinem Durmus, Sabri Sirolu, Bilun Gemicioglu, Sebuh Kurugoglu, Pinar Atukeren, Hafize Uzun, Fehmi Tabak |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
myalgia Turkey Cross-sectional study viruses Comorbidity Pulmonary Disease Chronic Obstructive Lung COPD biology virus diseases General Medicine Middle Aged respiratory system Hospitalization Infectious Diseases biochemical parameters Female medicine.symptom Adult medicine.medical_specialty Weakness RT-PCR Microbiology Chest CT Virology Internal medicine medicine Humans COVID-19 symptoms Aged Retrospective Studies Asthma SARS-CoV-2 business.industry COVID-19 Retrospective cohort study biochemical phenomena metabolism and nutrition medicine.disease Troponin respiratory tract diseases Cross-Sectional Studies biology.protein Parasitology Tomography X-Ray Computed business |
| Zdroj: | The Journal of Infection in Developing Countries. 15:1415-1425 |
| ISSN: | 1972-2680 |
| Popis: | Introduction: We aimed to evaluate clinical and laboratory findings of hospitalized asthma and chronic obstructive pulmonary disease (COPD) patients with COVID-19 and demonstrate that they have different symptoms and/or laboratory results and outcomes than COVID-19 patients with comorbidity (CoV-com) and without comorbidity (CoV-alone). Methodology: The data of the demographic, clinical, laboratory findings of hospitalized CoV-alone, asthma, COPD patients with COVID-19 (CoV-asthma, CoV-COPD, respectively), and CoV-com were analyzed. Results: Out of 1082 patients hospitalized for COVID-19, 585 (54.1%) had CoV-alone, 40 (3.7%) had CoV-asthma, 46 (4.3%) had CoV-COPD and 411 (38%) had CoV-com. Cough, shortness of breath, fever and weakness were the most common four symptoms seen in all COVID-19 patients. Shortness of breath, myalgia, headache symptoms were more common in CoV-asthma than the other groups (p < 0.001, p < 0.01, p < 0.05 respectively). Sputum was more common in CoV-COPD than other groups (p < 0.01). COPD group most frequently had increased values, different from the other groups with CRP>5ng/mL in 91.3%, D-dimer > 0.05mg/dL in 89.1%, troponin > 0.014micg/L in %63.9, INR>1.15 in 52.2%, CK-MB>25U/L in 48.5%, PT>14s in 40.9% of patients (p < 0.05, p < 0.001, p < 0.001, p < 0.001, p < 0.05, p < 0.001, respectively). NT-ProBNP was found to have the highest AUC value and the best differentiating parameter for CoV-asthma from CoV-alone. Typical CT findings were present in 44.4% of CoV-alone, 57.5% of CoV-asthma, 28.3% of CoV-COPD and 38.9% of CoV-com groups. CoV-COPD and CoV-com patients died more frequently than other groups (17.8%, 18.5%). Conclusions: CoV-asthma and CoV-COPD patients might have different symptoms and laboratory parameters than other COVID-19 patients which can guide the physicians. |
| Databáze: | OpenAIRE |
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