Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain
| Autor: | Olga Ciccarelli, Jan Lerut, Pierre-François Laterre, Juan Manuel Rico Juri, Benoît Lengelé, Chantal De Reyck, Eliano Bonaccorsi-Riani, Milton Inostroza Nunez, Pierre Gianello, Laurent Coubeau, Samuele Iesari, Pierre Goffette |
|---|---|
| Přispěvatelé: | UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de radiologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (SLuc) Service de chirurgie plastique, University of l'Aquila, Italy - Department of biotechnological and applied clinical sciences, Las Higueras Hospital, Talcahuano, Chile - Hepatobiliopancreatic Unit, Centro medico Imbanaco, Cali, Colombia - Cirugia de Trasplantes, UCL - (SLuc) Autre |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Graft Rejection Male Living-donor medicine.medical_specialty Hepatoblastoma medicine.medical_treatment 030230 surgery Liver transplantation Risk Assessment Hemangioendothelioma Cohort Studies Hospitals University 03 medical and health sciences 0302 clinical medicine Belgium Interquartile range Secondary liver tumor medicine Living Donors Hepatectomy Humans Retrospective Studies Donor hepatectomy Small-for-size graft Hepatocellular cancer Hepatology business.industry Graft Survival Liver Neoplasms Gastroenterology Age Factors Middle Aged medicine.disease Prognosis Survival Analysis Transplant Recipients Surgery Liver Transplantation Small-for-size syndrome Treatment Outcome Portal hypertension 030211 gastroenterology & hepatology Female Living donor liver transplantation business Liver Failure |
| Zdroj: | Hepatobiliary & Pancreatic Diseases International, Vol. 18, no. 2, p. 132-142 (2019) Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 18, no.2, p. 132-142 (2019) |
| Popis: | Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation (LDLT) is presented. A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29 (45.3%) females and 35 (54.7%) males was 50.2 years (interquartile range, IQR 32.9-57.5). Twenty-two (34.4%) recipients had no portal hypertension. Three (4.7%) patients had a benign and 33 (51.6%) a malignant tumor [19 (29.7%) hepatocellular cancer, 11 (17.2%) secondary cancer and one (1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months (IQR 41-159) and 39 months (22-91), respectively. Right and left hemi-livers were implanted in 39 (60.9%) and 25 (39.1%) cases, respectively. Median weights of right- and left-liver were 810 g (IQR 730-940) and 454 g (IQR 394-534), respectively. Graft-to-recipient weight ratios (GRWRs) were 1.17% (right, IQR 0.98%-1.4%) and 0.77% (left, 0.59%-0.95%). One- and five-year patient survivals were 85% and 71% (right) vs. 84% and 58% (left), respectively. One- and five-year graft survivals were 74% and 61% (right) vs. 76% and 53% (left), respectively. The patient and graft survival of right and left grafts and of very small ( |
| Databáze: | OpenAIRE |
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