KIR genes and their human leukocyte antigen ligands in the progression to cirrhosis in patients with chronic hepatitis C
| Autor: | Dayse Sousa de Pauli, Ricardo Alberto Moliterno, Giovanni Faria Silva, Camila Fernanda Verdichio de Moraes, Rejane Maria Tomasini Grotto, Amanda Vansan Marangon, Jeane Eliete Laguila Visentainer, Maria Inês de Moura Campos Pardini, Ana Maria Sell |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cirrhosis Genotype Hepatitis C virus KIR Ligand Immunology HLA-C Antigens Hepacivirus Human leukocyte antigen Biology Ligands Lymphocyte Activation medicine.disease_cause Immune system Gene Frequency Receptors KIR Fibrosis medicine Humans Immunology and Allergy Genetic Association Studies Polymorphism Genetic General Medicine Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Killer Cells Natural Liver Disease Progression Female Brazil |
| Zdroj: | Human Immunology. 72:1074-1078 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2011.08.017 |
| Popis: | Natural killer (NK) cells play pivotal roles in immune responses against infection with viruses, such as hepatitis C virus (HCV), and killer cell immunoglobulin-like receptors (KIRs) are related to the activation and inhibition of NK cells. The aim of this study was to investigate the possibility that KIR genes and their human leukocyte antigen (HLA) ligands influence progression to cirrhosis in patients infected with genotype 1 of HCV. A total of 145 Brazilian patients with confirmed chronic hepatitis C grouped from F0 to F4 according to fibrosis progression to cirrhosis were evaluated. Genotyping of KIR and HLA genes was performed by polymerase chain reaction with sequence-specific oligonucleotide probes. The HLA-C2 KIR ligand was more frequent in patients than in healthy controls (74.5% vs 64.3%, p = 0.04, odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.03–2.52). Moreover, the HLA-C1C2 genotype was more frequent in patients with advanced fibrosis or cirrhosis (F3–F4 group) than in patients in the F0–F2 group (61.6% vs 44.7%, p = 0.06) and in the F4 group compared with the F0–F3 group (65.7% vs 46.7%, p = 0.05, OR = 2.19, 95% CI = 1.01–4.73). NK and KIR ligands may contribute to the development of liver damage in patients chronically infected by HCV. |
| Databáze: | OpenAIRE |
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