Propofol decreases spike firing frequency with an increase in spike synchronization in the cerebral cortex
Autor: | Risako Kato, Yoshiyuki Oi, Masayuki Kobayashi, Mie Kajiwara |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Frequency band Action Potentials Inhibitory postsynaptic potential Insular cortex 03 medical and health sciences Bursting 0302 clinical medicine medicine Animals GABAergic Neurons Rats Wistar Infusions Intravenous Propofol Pharmacology Cerebral Cortex Chemistry lcsh:RM1-950 Electroencephalography Stimulation Chemical lcsh:Therapeutics. Pharmacology 030104 developmental biology medicine.anatomical_structure nervous system Cerebral cortex Excitatory postsynaptic potential Molecular Medicine GABAergic Neuroscience 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Journal of Pharmacological Sciences, Vol 142, Iss 3, Pp 83-92 (2020) |
ISSN: | 1347-8648 |
Popis: | Little is known about how propofol modulates the spike firing correlation between excitatory and inhibitory cortical neurons in vivo. We performed extracellular unit recordings from rat insular cortical neurons, and classified neurons with high spontaneous firing frequency, bursting, and short spike width as high frequency with bursting neurons (HFB; pseudo fast-spiking GABAergic neurons) and other neurons with low spontaneous firing frequency and no bursting were classified as non-HFB. Intravenous administration of propofol (12 mg/kg) from the caudal vein reduced the firing frequency of HFB, whereas propofol initially increased (within 30 s) and then decreased the firing frequency of non-HFB. Both HFB and non-HFB spontaneous action potential discharge was depressed by propofol with a greater depression seen for HFB. Cross-correlograms and auto-correlograms demonstrated propofol-induced increases in the ratio of the peak, which were mostly observed around 0–10 ms divided to baseline amplitude. The analysis of interspike intervals showed a decrease in spike firing at 20–100 Hz and a relative increase at 8–15 Hz. These results suggest that propofol induces a larger suppression of firing frequency in HFB and an enhancement of synchronized neural activities in the α frequency band in the cerebral cortex (192 words). Keywords: General anesthetics, Insular cortex, Synchronization, GABAergic neuron, Awake |
Databáze: | OpenAIRE |
Externí odkaz: |