Cyclin D in left ventricle hypertrophy
| Autor: | Peter Kamp Busk, Rebecca Hinrichsen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty biology Kinase Cyclin D Cardiomyopathy Cell Biology Cell cycle medicine.disease Models Biological Muscle hypertrophy Cell biology Endocrinology Internal medicine Heart failure medicine biology.protein Myocyte Humans Cyclin D1 Hypertrophy Left Ventricular Molecular Biology Developmental Biology Cyclin Signal Transduction |
| Zdroj: | Cell cycle (Georgetown, Tex.). 2(2) |
| ISSN: | 1538-4101 |
| Popis: | Left ventricle hypertrophy is induced by a number of stimuli and can lead to cardio-myopathy and heart failure. The hypertrophic response is achieved by enlargement of the cardiac myocytes and is regulated by multiple signaling pathways, with the D-type cyclins playing a crucial role. Induction of cyclin D in adult cardiac myocytes leads to activation of cyclin-dependent kinases 4 and 6 and a partial progress through the cell cycle. Therefore, these pathways are attractive therapeutic target for treatment of heart failure and hypertrophy. We discuss the activity of cyclin D and other cell cycle regulatory proteins in left ventricle hypertrophy and whether the hypertrophic signaling pathways converge at the D-type cyclins. |
| Databáze: | OpenAIRE |
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