Skeletal muscle response to spaceflight, whole body suspension, and recovery in rats
| Autor: | R. D. Fell, J. M. Steffen, X. J. Musacchia, M. J. Dombrowski |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Physiology Muscle mass Spaceflight law.invention Extensor digitorum muscle Reference Values law Physiology (medical) Internal medicine medicine Animals Soleus muscle Weightlessness Chemistry Muscles musculoskeletal neural and ocular physiology Skeletal muscle Rats Inbred Strains Organ Size Anatomy Space Flight musculoskeletal system Muscle atrophy Capillaries Hindlimb Rats medicine.anatomical_structure Endocrinology medicine.symptom Whole body |
| Zdroj: | Journal of Applied Physiology. 69:2248-2253 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1990.69.6.2248 |
| Popis: | Comparisons of soleus and extensor digitorum longus (EDL) muscles from male Sprague-Dawley rats (350-400 g) after 7 days of weightlessness, 7 and 14 days of whole body suspension (WBS), and 7 days of recovery from WBS and from vivarium controls were made. Muscle mass loss of approximately 30% was observed in soleus after 7 and 14 days of WBS. Measurement of slow- and fast-twitch fibers showed significant alterations. Reductions in cross-sectional areas and increases in fiber densities in soleus after spaceflight and WBS were related to previous findings of muscle atrophy during unloading. Capillary density also showed a marked increase with unloading. Seven days of weightlessness were sufficient to effect a 20 and 15% loss in absolute muscle mass in soleus and EDL, respectively. However, the antigravity soleus was more responsive in terms of cross-sectional area reductions. After 7 days of recovery from WBS, with normal ambulatory loading, the parameters studied showed a reversal to control levels. Muscle plasticity, in terms of fiber and capillary responses, indicated differences in responses in the two types of muscles and further amplified that antigravity posture muscles are highly susceptible to unloading. Studies of recovery from spaceflight for both muscle metabolism and microvascular modifications are further justified. |
| Databáze: | OpenAIRE |
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