The impact of age, sex, cardio-respiratory fitness, and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity

Autor: Joseph D. Maxwell, Daniel J. Bannell, Aine Brislane, Sophie E. Carter, Gemma D. Miller, Kirsty A. Roberts, Nicola D. Hopkins, David A. Low, Howard H. Carter, Andrew Thompson, Jurgen A. H. R. Claassen, Dick H. J. Thijssen, Helen Jones
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Applied Physiology, 122, 6, pp. 1531-1541
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
European Journal of Applied Physiology, 122, 1531-1541
ISSN: 1439-6327
1439-6319
DOI: 10.1007/s00421-022-04933-3
Popis: Background Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP), but changes in the underlying control mechanisms across the lifespan are less well understood. We aimed to; (1) examine the impact of age, sex, cardiovascular disease (CVD) risk, and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity, and (2) explore the relationships between dynamic cerebral autoregulation (dCA) and cardiac baroreflex sensitivity (cBRS). Methods 206 participants aged 18–70 years were stratified into age categories. Cerebral blood flow velocity was measured using transcranial Doppler ultrasound. Repeated squat-stand manoeuvres were performed (0.10 Hz), and transfer function analysis was used to assess dCA and cBRS. Multivariable linear regression was used to examine the influence of age, sex, CVD risk, and cardio-respiratory fitness on dCA and cBRS. Linear models determined the relationship between dCA and cBRS. Results Age, sex, CVD risk, and cardio-respiratory fitness did not impact dCA normalised gain, phase, or coherence with minimal change in all models (P > 0.05). cBRS gain was attenuated with age when adjusted for sex and CVD risk (young–older; β = − 2.86 P β = − 0.44, P Conclusion Ageing was associated with a decreased cBRS, but dCA appears to remain unchanged. Additionally, our data suggest that sex, CVD risk, and cardio-respiratory fitness have little effect.
Databáze: OpenAIRE
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