Effects of Labisia pumila on bone turnover markers and OPG/RANKL system in a rat model of post-menopausal osteoporosis
| Autor: | Nicolaas Budhiparama, Bambang Setiawan, Zairin Noor, Nelly Mariati, Nurdiana Nurdiana, Noorhamdani Noorhamdani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases medicine.medical_specialty Endocrinology Diabetes and Metabolism Rat model Osteoporosis lcsh:TX341-641 Bone remodeling 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Nutrition and Dietetics biology business.industry Labisia pumila biology.organism_classification medicine.disease Resorption 030104 developmental biology Endocrinology RANKL Ovariectomized rat Osteocalcin biology.protein business lcsh:Nutrition. Foods and food supply 030217 neurology & neurosurgery |
| Zdroj: | Clinical Nutrition Experimental, Vol 20, Iss, Pp 41-47 (2018) |
| ISSN: | 2352-9393 |
| Popis: | Summary: The loss of bone mass due to the increasing age in women is caused by the decline in ovarian function, known as osteoporosis. Numerous studies have evaluated the benefits of Labisia pumila, but not investigated the OPG/RANKL system. The purpose of the present study was to analyze the effects of L. pumila extract on bone turnover markers and OPG/RANKL system in ovariectomized rats. Totally, twenty-five female Wistar rats were divided into five tgroups (n = 5), including the control group, ovariectomized group, ovariectomized group treated with L. pumila extract of various doses (10 mg/kg; 20 mg/kg and 40 mg/kg). L. pumila extract was administered daily for 8 weeks. Serum levels of osteocalcin, urine levels of deoxypiridinoline, serum levels of OPG and RANKL were analyzed by means of ELISA technique. Serum levels of deoxypiridinoline and urine levels of osteocalcin were significantly higher in the ovariectomized group than those of the control group (p 0.05). In conclusion, the ethanol extract of L. pumila normalized osteoblastic bone formation, but could not prevent collagen degradation in bone in a rat model of post-menopausal osteoporosis. Keywords: Ovariectomy, Resorption, Formation, Osteoporosis, ‘Fatimah’ grass |
| Databáze: | OpenAIRE |
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