Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus

Autor:	Elise Melloul, Marie-Laure Dardé, Françoise Botterel, Marie-Fleur Durieux, Eric Dannaoui, Jacques Guillot, Lolita Roisin, Sana Jemel
Přispěvatelé:	Service de Parasitologie Mycologie [CHU Limoges], CHU Limoges, Dynamic Microbiology - EA 7380 (DYNAMIC), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), École nationale vétérinaire - Alfort (ENVA), Unité de Parasitologie-Mycologie [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique et Maladies Infectieuses 94000 Créteil, France, Grelier, Elisabeth
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Microbiology (medical) animal structures mini-host model Immunology Mutant review virulence factors Virulence Review Article Infectious and parasitic diseases RC109-216 Microbiology Aspergillus fumigatus 03 medical and health sciences Screening tool 030304 developmental biology galleria mellonella 0303 health sciences biology 030306 microbiology fungi aspergillus fumigatus biochemical phenomena metabolism and nutrition biology.organism_classification Pathogenicity Galleria mellonella Infectious Diseases [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Parasitology
Zdroj:	Virulence, Vol 12, Iss 1, Pp 818-834 (2021) Virulence article-version (VoR) Version of Record Virulence, 2021, 12 (1), p. 818-834. ⟨10.1080/21505594.2021.1893945⟩
ISSN:	2150-5608 2150-5594
Popis:	International audience; The invertebrate Galleria mellonella has increasingly and widely been used in the last few years to study complex host-microbe interactions. Aspergillus fumigatus is one of the most pathogenic fungi causing life-threatening diseases in humans and animals. Galleria mellonella larvae has been proven as a reliable model for the analysis of pathogenesis and virulence factors, enable to screen a large number of A. fumigatus strains. This review describes the different uses of G. mellonella to study A. fumigatus and provides a comparison of the different protocols to trace fungal pathogenicity. The review also includes a summary of the diverse mutants tested in G. mellonella, and their respective contribution to A. fumigatus virulence. Previous investigations indicated that G. mellonella should be considered as an interesting tool even though a mammalian model may be required to complete and verify initial data.
Databáze:	OpenAIRE
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