Efficient and Regioselective N-1 Alkylation of 4-Chloropyrazolo[3,4-d]pyrimidine
Autor: | Morten Brændvang, Lise-Lotte Gundersen |
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Rok vydání: | 2007 |
Předmět: | |
Zdroj: | ChemInform. 38 |
ISSN: | 1522-2667 0931-7597 |
Popis: | Efficient and N-1 selective alkylation of 4-chloropyrazolo[3,4-d]pyrimidine can be achieved when the heterocycle is reacted with alcohols under Mitsunobu conditions. The 1-alkyl-pyrazolo[3,4-d]pyrimidines formed can be functionalized further according to known methods, to give a variety of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines. The first example of a palladium-catalyzed coupling reaction on a 4-halopyrazolo[3,4-d]pyrimidine is described. |
Databáze: | OpenAIRE |
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