Efficient and Regioselective N-1 Alkylation of 4-Chloropyrazolo[3,4-d]pyrimidine

Autor:	Morten Brændvang, Lise-Lotte Gundersen
Rok vydání:	2007
Předmět:	chemistry.chemical_compound Pyrimidine Chemistry Organic Chemistry Drug Discovery Organic chemistry Regioselectivity General Medicine Alkylation Biochemistry Combinatorial chemistry Coupling reaction
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
Popis:	Efficient and N-1 selective alkylation of 4-chloropyrazolo[3,4-d]pyrimidine can be achieved when the heterocycle is reacted with alcohols under Mitsunobu conditions. The 1-alkyl-pyrazolo[3,4-d]pyrimidines formed can be functionalized further according to known methods, to give a variety of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines. The first example of a palladium-catalyzed coupling reaction on a 4-halopyrazolo[3,4-d]pyrimidine is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2e5275812141d91a3f5eb5dc7356f https://doi.org/10.1002/chin.200733146 Zobrazit plný text záznamu Plný text