T Cell receptor expression by T cells that mature extrathymically in nude mice
| Autor: | C W Pierce, Jeffrey D. Kennedy, Jeffrey P. Lake |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte medicine.medical_specialty CD3 Complex CD8 Antigens T-Lymphocytes Cellular differentiation CD3 Immunology Receptors Antigen T-Cell Mice Nude chemical and pharmacologic phenomena Spleen Flow cytometry Mice Internal medicine medicine Animals Cytotoxic T cell medicine.diagnostic_test biology T-cell receptor hemic and immune systems T lymphocyte Molecular biology Mice Inbred C57BL medicine.anatomical_structure Endocrinology CD4 Antigens biology.protein Lymph Nodes CD8 |
| Zdroj: | Cellular Immunology. 135:259-265 |
| ISSN: | 0008-8749 |
| Popis: | The expression of TCR by T cells that mature extrathymically in nude mice was determined by staining Ig − cells from B10 nude mice that were 5 months of age or older with mAbs specific for CD3, α β or γ δ TCR. Although the majority of Ig − cells in older nude mice express TCR, the distribution of α β and γ δ TCR in relation to CD4 and CD8 expression is markedly different compared to T cells from euthymic mice. Approximately half of the CD3 + T cells found in the spleen and lymph nodes of nude mice express γ δ TCR that is equally distributed between CD4 − 8 − double-negative and CD8 + single-positive T cells. These data provide the first quantitative measure of the expression of TCR by T cells that mature in the absence of a thymus and suggest that the extrathymic environment, although not efficient, is permissive for the maturation of T cells that express α β and γ δ TCR. |
| Databáze: | OpenAIRE |
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