Animal models of cathartic colon
| Autor: | En Kang Wang, Jian Ye Yuan, Qiao Li Sun, Linda Zhong, Ya Feng, Qiao Dong Li, Jie Liu, Yang Yang Meng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
business.industry
medicine.medical_treatment Laxative Diphenylmethane Minireviews Anthraquinones General Medicine Cathartic colon Anthraquinone laxatives Bioinformatics 03 medical and health sciences 0302 clinical medicine Animal model Modelling methods 030220 oncology & carcinogenesis Medicine Effective treatment 030211 gastroenterology & hepatology business Constipation |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| Popis: | The incidence of cathartic colon has been increasing, but satisfactory treatments are still lacking. In order to study the pathological mechanisms of the disorder and identify effective treatment methods, researchers have established different animal models of cathartic colon. This minireview briefly summarizes several common cathartic colon animal models, induced with anthraquinone laxatives such as rhubarb, total anthraquinone, rhein, and emodin, or induced with diphenylmethane laxatives such as phenolphthalein. The advantages and limitations of these models are evaluated and analyzed. We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods. We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans, and serve as useful tools for further studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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