Serum levels of CC16, SP-A and SP-B reflect tobacco-smoke exposure in asymptomatic subjects
| Autor: | Marjorie Robin, Ian R. Doyle, Cédric Hermans, Alfred Bernard, Ping Dong, Andrew D. Bersten |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine Adolescent Physiology Asymptomatic Tobacco smoke chemistry.chemical_compound Parenchyma medicine Humans Uteroglobin Creatinine Pulmonary Surfactant-Associated Protein B Pulmonary Surfactant-Associated Protein A business.industry Smoking Age Factors Proteins Pulmonary Surfactants Middle Aged Pathophysiology medicine.anatomical_structure VEMS chemistry Toxicity Immunology Respiratory Mechanics medicine.symptom business Respiratory tract |
| Zdroj: | European Respiratory Journal. 20:1152-1161 |
| ISSN: | 1399-3003 0903-1936 |
| Popis: | Since the 16-kDa bronchiolar Clara cell protein (CC16) and the alveolar surfactant-associated proteins (SP)-A and -B leak into the circulation when parenchymal health is disturbed, the aim of this study was to determine whether their serum levels could serve as early peripheral markers of tobacco smoke-induced epithelial injury. Sixty-nine (51 yrs (32-54) median (25-75th percentile)) nonsmokers and 54 (42 yrs (31-53)) asymptomatic smokers were enrolled in the study. Serum levels of SP-A did not differ between subjects (270 (208-389) versus 259 (168-392) microg x L(-1)), however, CC16 levels decreased (10.6 (8.7-14.6) versus 7.6 (6.0-11.2) microg x L(-1)) and SP-B levels increased (2,529 (2,091-2,943) versus 3,053 (2,613-4,188) microg x L(-1)) in the smokers. When tobacco smoke exposure, serum creatinine (renal index), age and sex were used as independent variables, CC16 was negatively influenced by cumulative smoking and positively influenced by age. SP-A and -B were negatively influenced by creatinine and positively influenced by cumulative smoking. Serum SP-B was inversely correlated with forced expiratory volume in one second/vital capacity, suggesting an association between obstructive disease and parenchymal lung health. The authors suggest that serum surfactant-associated proteins-A and -B reflect increased alveolocapillary leakage whereas Clara cell secretory protein 16 reflects tobacco smoke-induced Clara cell toxicity. Their evaluation may allow the effects of tobacco smoke on different levels of the respiratory tract, cellular toxicity and epithelial leakage to be distinguished. |
| Databáze: | OpenAIRE |
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