Global gene expression by Bacillus anthracis during growth in mammalian blood
| Autor: | Philip C. Hanna, Paul E. Carlson, Ada K. Hagan, Alexandra E. T. Bourgis |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Genetics General Immunology and Microbiology Gene Expression Profiling Virulence General Medicine Shortomics Biology biology.organism_classification Genome Bacillus anthracis Microbiology Transcriptome Gene expression profiling Infectious Diseases Blood Gene expression Immunology and Allergy Macrophage Animals Cattle Gene |
| Popis: | During the late stages of systemic anthrax, Bacillus anthracis grows rapidly in the host bloodstream. To identify potential genes necessary for this observed rapid growth, we defined the transcriptional profile of B. anthracis during in vitro growth in bovine blood. Genome-wide transcriptome analysis indicated that B. anthracis undergoes significant changes in its transcriptome profile during growth in blood, including the differential regulation of genes associated both with metabolism and known virulence factors. Collectively, these data provide a framework for future studies identifying specific B. anthracis factors required for growth in the mammalian bloodstream. |
| Databáze: | OpenAIRE |
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