A cross-over trial comparing once daily levobunolol with once and twice daily timolol
| Autor: | S. K. Akafo, A. R. Rosenthal, J. R. Thompson |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Intraocular pressure genetic structures Open angle glaucoma Eye disease Adrenergic beta-Antagonists Levobunolol Timolol Drug Administration Schedule Double blind 03 medical and health sciences 0302 clinical medicine Double-Blind Method Medicine Humans Intraocular Pressure Aged Aged 80 and over Cross-Over Studies business.industry General Medicine Middle Aged medicine.disease Crossover study eye diseases Ophthalmology Anesthesia 030221 ophthalmology & optometry Female Ocular Hypertension sense organs Once daily Ophthalmic Solutions business 030217 neurology & neurosurgery Glaucoma Open-Angle medicine.drug |
| Zdroj: | European journal of ophthalmology. 5(3) |
| ISSN: | 1120-6721 |
| Popis: | The intraocular pressure (IOP) lowering efficacy of once-daily levobunolol 0.5% was compared with timolol 0.5% twice-daily and timolol 0.5% once-daily in 20 chronic open angle glaucoma and 5 ocular hypertensive patients. The design used was a randomised double blind cross-over trial with three periods each of 8 weeks separated by 2 weeks of no treatment. We found that following levobunolol a two week washout was not sufficient for the IOP to return to its original baseline level suggesting that levobunolol is a longer acting drug than timolol. Adjusting for this carryover effect, we found no significant difference in the IOP lowering effect among the three regimes (p=0.53). Reduced cost, less ocular discomfort and better compliance are the main potential advantages of the once daily treatments. |
| Databáze: | OpenAIRE |
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