Production of a Cytotoxin by Helicobacter pylori
| Autor: | Robert D. Leunk |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Microbiology (medical)
medicine.disease_cause Neutralization Helicobacter Infections Microbiology In vivo medicine Humans Helicobacter pylori biology Cytotoxins Toxin business.industry bacterial infections and mycoses biology.organism_classification Virology digestive system diseases Infectious Diseases biology.protein bacteria Antibody Gastritis medicine.symptom business Intracellular Bacteria |
| Zdroj: | Clinical Infectious Diseases. 13:S686-S689 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/13.supplement_8.s686 |
| Popis: | Helicobacter pylori produces a cytotoxin that was initially detected as the ability of broth culture filtrates of this bacterium to induce intracellular vacuolation of cultured cells. Fifty-three percent of more than 200 isolates of H. pylori tested produce the cytotoxin, which appears to be unique to H. pylori. Results of characterization studies suggest that the cytotoxin is a high-molecular-weight protein. Detection of serum antibody to the cytotoxin by neutralization or immunoblotting indicates that this toxin is produced in vivo. The cytotoxin is more frequently associated with cases of peptic ulceration than with cases of gastritis; this finding suggests that the toxin contributes to the severity of disease associated with H. pylori infection. |
| Databáze: | OpenAIRE |
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