The maximum chemiluminescence intensity predicts severe neutropenia in gemcitabine-treated patients with pancreatic or biliary tract cancer

Autor: Sayaka Arisaka, Toshiaki Kadokura, Itaru Endo, Ryusei Matsuyama, Koki Goto, Takafumi Kumamoto, Ryutaro Mori, Masataka Taguri, Yusuke Suwa, Mari Sato
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Cancer Research
Chemiluminescence
Neutrophils
Toxicology
Gastroenterology
Deoxycytidine
Severity of Illness Index
law.invention
0302 clinical medicine
law
Pharmacology (medical)
medicine.diagnostic_test
Gencitabine
Neoadjuvant Therapy
Titer
Biliary Tract Neoplasms
Oncology
030220 oncology & carcinogenesis
Absolute neutrophil count
Original Article
Female
medicine.drug
medicine.medical_specialty
Antimetabolites
Antineoplastic
Neutropenia
Tegafur
Neoadjuvant chemotherapy
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Pancreatic cancer
medicine
Blood test
Humans
Aged
Retrospective Studies
Pharmacology
business.industry
medicine.disease
Gemcitabine
Pancreatic Neoplasms
030104 developmental biology
Luminescent Measurements
Biliary tract cancer
business
Zdroj: Cancer Chemotherapy and Pharmacology
ISSN: 1432-0843
0344-5704
Popis: Purpose To assess the predictive ability of the maximum chemiluminescence intensity (CImax) for severe neutropenia (SN) during neoadjuvant chemo(radio)therapy [NAC(RT)] in patients with advanced pancreatic or biliary tract cancer. Methods Clinicopathological variables and blood test data before NAC(RT) were evaluated in 64 patients with advanced pancreatic or biliary tract cancer who received gemcitabine plus tegafur/gimeracil/oteracil as NAC(RT). Results Thirty-nine patients (60.9%) developed Grade 3–4 SN. The median time between commencing NAC(RT) and the onset of SN was 15 (range 10–36) days. SN occurred during the NAC period, not the RT period. The CImax, neutrophil count, serum interleukin-6 level, C-reactive protein level, complement C3 titer, serum complement titer, and 50.0% hemolytic unit of complement before NAC(RT) were significantly lower in patients with SN than in those without SN (P
Databáze: OpenAIRE
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