RNA ENGINEERING FOR PUBLIC HEALTH: INNOVATIONS IN RNA-BASED DIAGNOSTICS AND THERAPEUTICS
| Autor: | Walter Thavarajah, Chloeacute M. Archuleta, Julius B. Lucks, David Z. Bushhouse, Laura M. Hertz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Renewable Energy Sustainability and the Environment General Chemical Engineering RNA General Chemistry Computational biology Biology Article 03 medical and health sciences Synthetic biology 0302 clinical medicine Gene expression Extracellular CRISPR Synthetic Biology Public Health Genetic Engineering Expansive 030217 neurology & neurosurgery Function (biology) 030304 developmental biology |
| Zdroj: | Annu Rev Chem Biomol Eng |
| Popis: | RNA is essential for cellular function: From sensing intra- and extracellular signals to controlling gene expression, RNA mediates a diverse and expansive list of molecular processes. A long-standing goal of synthetic biology has been to develop RNA engineering principles that can be used to harness and reprogram these RNA-mediated processes to engineer biological systems to solve pressing global challenges. Recent advances in the field of RNA engineering are bringing this to fruition, enabling the creation of RNA-based tools to combat some of the most urgent public health crises. Specifically, new diagnostics using engineered RNAs are able to detect both pathogens and chemicals while generating an easily detectable fluorescent signal as an indicator. New classes of vaccines and therapeutics are also using engineered RNAs to target a wide range of genetic and pathogenic diseases. Here, we discuss the recent breakthroughs in RNA engineering enabling these innovations and examine how advances in RNA design promise to accelerate the impact of engineered RNA systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|