A randomized clinical trial for the timing of tracheotomy in critically ill patients: factors precluding inclusion in a single center study
| Autor: | Neus Sampietro, Antonio Diaz-Prieto, Rafael Mañez, Berta Ortiga, Maite Gorriz, Consol Truchero, Antoni Mateu, María Jesus Ferrer |
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| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Randomization Adolescent Critical Illness Sedation medicine.medical_treatment Critical Care and Intensive Care Medicine Single Center Respiració artificial law.invention Young Adult Tracheotomy Randomized controlled trial law medicine Humans Prospective Studies Prospective cohort study Aged Aged 80 and over Mechanical ventilation Intention-to-treat analysis business.industry Research Middle Aged Respiration Artificial Surgery Artificial respiration Female medicine.symptom business Traqueotomia |
| Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Critical Care |
| Popis: | Introduction We investigated the potential benefits of early tracheotomy performed before day eight of mechanical ventilation (MV) compared with late tracheotomy (from day 14 if it still indicated) in reducing mortality, days of MV, days of sedation and ICU length of stay (LOS). Methods Randomized controlled trial (RCT) including all-consecutive ICU admitted patients requiring seven or more days of MV. Between days five to seven of MV, before randomization, the attending physician (AP) was consulted about the expected duration of MV and acceptance of tracheotomy according to randomization. Only accepted patients received tracheotomy as result of randomization. An intention to treat analysis was performed including patients accepted for the AP and those rejected without exclusion criteria. Results A total of 489 patients were included in the RCT. Of 245 patients randomized to the early group, the procedure was performed for 167 patients (68.2%) whereas in the 244 patients randomized to the late group was performed for 135 patients (55.3%) (P |
| Databáze: | OpenAIRE |
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