Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377)
| Autor: | Michael Wantman, Andrew Wiznia, Paul Palumbo, Paul Krogstad, Lee Jen Wei, Shawn Cunningham, Susan H. Eshleman, Sharon A Nachman, George M. Johnson, You-Gan Wang, Sophia Lee, J. Brooks Jackson |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Pediatric AIDS Nevirapine Adolescent Genotype Anti-HIV Agents HIV Infections Biology Cohort Studies Zalcitabine immune system diseases Antiretroviral Therapy Highly Active medicine Immunology and Allergy Humans Treatment Failure Child Didanosine Nelfinavir Ritonavir Stavudine virus diseases Lamivudine Infant Drug Resistance Microbial Viral Load Virology Infectious Diseases Child Preschool Mutation HIV-1 RNA Viral Reverse Transcriptase Inhibitors Female medicine.drug |
| Zdroj: | The Journal of infectious diseases. 183(12) |
| ISSN: | 0022-1899 |
| Popis: | In Pediatric AIDS Clinical Trials Group 377, antiretroviral therapy-experienced children were randomized to 4 treatment arms that included different combinations of stavudine, lamivudine (3TC), nevirapine (Nvp), nelfinavir (Nfv), and ritonavir (Rtv). Previous treatment with zidovudine (Zdv), didanosine (ddI), or zalcitabine (ddC) was acceptable. Drug resistance ((R)) mutations were assessed before study treatment (baseline) and at virologic failure. Zdv(R), ddI(R), and ddC(R) mutations were detected frequently at baseline but were not associated with virologic failure. Children with drug resistance mutations at baseline had greater reductions in virus load over time than did children who did not. Nvp(R) and 3TC(R) mutations were detected frequently at virologic failure, and Nvp(R) mutations were more common among children receiving 3-drug versus 4-drug Nvp-containing regimens. Children who were maintained on their study regimen after virologic failure accumulated additional Nvp(R) and 3TC(R) mutations plus Rtv(R) and Nfv(R) mutations. However, Rtv(R) and Nfv(R) mutations were detected at unexpectedly low rates. |
| Databáze: | OpenAIRE |
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