Insertion/Insertion Genotype of Angiotensin I-Converting-Enzyme Gene Predicts Risk of Myocardial Infarction in North East India
| Autor: | Mriganka S Chaliha, Prasanta Kumar Borah, Jagadish Mahanta, Rashmi Rajkakati, Sukanya Baruah, P. K. Borua |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Myocardial Infarction India Physical examination Disease 030204 cardiovascular system & hematology Biology Peptidyl-Dipeptidase A Biochemistry 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Genotype Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease Myocardial infarction Gene–environment interaction Molecular Biology Ecology Evolution Behavior and Systematics Genetic Association Studies Aged Polymorphism Genetic medicine.diagnostic_test Case-control study General Medicine Odds ratio Middle Aged medicine.disease Mutagenesis Insertional 030104 developmental biology Case-Control Studies Female Gene Deletion |
| Zdroj: | Biochemical genetics. 54(2) |
| ISSN: | 1573-4927 |
| Popis: | Myocardial infarction (MI) is common in India and the disease occurs at a relatively younger age. We wanted to look for association of Angiotensin I-converting enzyme (ACE) gene with MI in North East India. We also wanted to examine possible environmental interaction of ACE gene with established cardiovascular risk factors in causation of MI. In the study carried out in Assam Medical College, 200 consecutive confirmed cases of MI were recruited. Equal numbers of age- and sex-matched control subjects from hospital workers and patients attending the hospital for diseases unrelated to cardiovascular disease were enrolled. Structured questionnaires were used to note demographic and clinical factors. Cardiovascular risk factors were determined from history, physical examination and biochemical investigations. ACE insertion/deletion (I/D) polymorphism was determined by PCR method. Interaction of ACE gene with other risk factors was noted. The study identified ACE II genotype (odds ratio = 3.02; 95% CI 1.40-6.51), smoking, hypertension, diabetes and serum triglyceride > 150 mg/dl as independent risk factors for MI. ACE II genotype showed greater risk in non-smokers, non-hypertensives, non-diabetics and in subjects with LDL-C < 130 mg/dl. Low HDL cholesterol enhanced the genetic risk. Subjects with ACE II genotype have an independent risk of developing MI, specially in low cardiovascular risk subjects. |
| Databáze: | OpenAIRE |
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