Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

Autor:	Andreas Marx, Meng Zheng, Kathrin H. Götz, Martin Mex
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine chemistry.chemical_classification Poly Adenosine Diphosphate Ribose Chemistry Drug discovery Poly ADP ribose polymerase Organic Chemistry Poly (ADP-Ribose) Polymerase-1 Disaccharide Cancer therapy Chemistry Techniques Synthetic Poly(ADP-ribose) Polymerase Inhibitors Disaccharides Biochemistry In vitro 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Enzyme Drug Discovery ddc:540 Humans Physical and Theoretical Chemistry Nucleoside
Popis:	Poly(ADP-ribose) polymerase-1 (PARP-1) is an important target in cancer therapy. We present the synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) and test their inhibitory effects on human PARP-1. Some compounds show inhibition of enzymatic activity in vitro and thus might be interesting for further investigations. published
Databáze:	OpenAIRE
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