Level of education mitigates the impact of tau pathology on neuronal function
| Autor: | Gereon R. Fink, Merle C Hoenig, Gérard N. Bischof, Alzheimer’s Disease Neuroimaging Initiative, Juraj Kukolja, Thilo van Eimeren, Klaus Fliessbach, Elke Kalbe, Özgür A. Onur, Alexander Drzezga, Bernd Neumaier, Frank Jessen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty Tau pathology tau Proteins Disease physiopathology [Alzheimer Disease] 030218 nuclear medicine & medical imaging 03 medical and health sciences pathology [Alzheimer Disease] 0302 clinical medicine Alzheimer Disease Internal medicine mental disorders Medicine Humans pathology [Neurons] Radiology Nuclear Medicine and imaging In patient ddc:610 Cognitive reserve Aged Neurons business.industry Mean age General Medicine Pet imaging metabolism [tau Proteins] Mmse score 030220 oncology & carcinogenesis Positron-Emission Tomography Educational Status Female business diagnostic imaging [Alzheimer Disease] metabolism [Alzheimer Disease] |
| Zdroj: | European journal of nuclear medicine and molecular imaging 46(9), 1787-1795 (2019). doi:10.1007/s00259-019-04342-3 European journal of nuclear medicine and molecular imaging 46(9), 1787–1795 (2019). doi:10.1007/s00259-019-04342-3 |
| DOI: | 10.1007/s00259-019-04342-3 |
| Popis: | PurposeUsing PET imaging in a group of patients with Alzheimer’s disease (AD), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function.MethodsWe included 38 patients with mild-to-moderate AD (mean age 67 ± 7 years, mean MMSE score 24 ± 4, mean years of education 14 ± 4; 20 men, 18 women) in whom a [18F]AV-1451 scan (a measure of tau pathology) and an [18F]FDG scan (a measure of neuronal function) were available. The preprocessed PET scans were z-transformed using templates for [18F]AV-1451 and [18F]FDG from healthy controls, and subsequently thresholded at a z-score of ≥3.0, representing an one-tailed p value of 0.001. Next, three volumes were computed in each patient: the tau-specific volume (tau pathology without neuronal dysfunction), the FDG-specific volume (neuronal dysfunction without tau pathology), and the overlap volume (tau pathology and neuronal dysfunction). Mean z-scores and volumes were extracted and used as dependent variables in regression analysis with years of education as predictor, and age and MMSE score as covariates.ResultsYears of education were positively associated with tau-specific volume (β = 0.362, p = 0.022), suggesting a lower impact of tau pathology on neuronal function in patients with higher levels of education. Concomitantly, level of education was positively related to tau burden in the overlap volume (β = 0.303, p = 0.036) implying that with higher levels of education more tau pathology is necessary to induce neuronal dysfunction.ConclusionIn patients with higher levels of education, tau pathology is less paralleled by regional and remote neuronal dysfunction. The data suggest that early life-time factors such as level of education support resilience mechanisms, which ameliorate AD-related effects later in life. |
| Databáze: | OpenAIRE |
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