Bilateral transcranial magnetic stimulation of the supplementary motor area in children with Tourette syndrome
| Autor: | Rose Swansburg, James G. Wrightson, Tamara Pringsheim, Lisa Marie Langevin, Paul E. Croarkin, Ephrem Zewdie, Frank P. MacMaster, Cynthia Kahl, Adam Kirton |
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| Rok vydání: | 2021 |
| Předmět: |
Male
030506 rehabilitation medicine.medical_specialty Adolescent medicine.medical_treatment Tourette syndrome 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Developmental Neuroscience Motor system medicine Humans Child Depression (differential diagnoses) Supplementary motor area medicine.diagnostic_test business.industry Motor Cortex medicine.disease SMA Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation Treatment Outcome medicine.anatomical_structure Pediatrics Perinatology and Child Health Anxiety Female Neurology (clinical) medicine.symptom 0305 other medical science business Functional magnetic resonance imaging human activities 030217 neurology & neurosurgery Tourette Syndrome |
| Zdroj: | Developmental Medicine & Child Neurology. 63:808-815 |
| ISSN: | 1469-8749 0012-1622 |
| DOI: | 10.1111/dmcn.14828 |
| Popis: | AIM To explore the feasibility and possible effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) delivered to the supplementary motor area (SMA) on tic severity and motor system neurophysiology in children with Tourette syndrome. METHOD Ten children with Tourette syndrome (eight males, two females; 9-15y) participated in this open-label, phase 1 clinical trial. Treatment consisted of 1800 low-frequency (1Hz) neuronavigated robotic rTMS (100% resting motor threshold) to the SMA, bilaterally for 15 sessions. The primary outcome was a change in Yale Global Tic Severity Scale (YGTSS) total score from baseline to posttreatment. Secondary outcome measures included changes in magnetic resonance spectroscopy metabolite concentrations, TMS neurophysiology measures, TMS motor maps, and clinical assessments (anxiety, depression) from baseline to the end of treatment. RESULTS The YGTSS score decreased from baseline after treatment (p |
| Databáze: | OpenAIRE |
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