The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers
| Autor: | Pei Yi Chong, Chee Wee Ong, Manuel Salto-Tellez, Alan Prem Kumar, Sandra Van Schaeybroeck, Richie Soong, Marie-Veronique Clement, Jason Yongsheng Chan, Philip D Dunne, Darragh G. McArt, Patrick G. Johnston, Maxey C. M. Chung, Hwee Tong Tan, David Waugh |
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| Přispěvatelé: | Ong, Chee Wee, Chong, Pei Yi, McArt, Darragh G, Chan, Jason Yongsheng, Tan, Hwee Tong, Kumar, Alan Prem, Chung, Maxey CM, Clement, Marie Veronique, Soong, Richie, Van Schaeybroeck, Sandra, Waugh, David JJ, Johnston, Patrick G, Dunne, Philip D, Salto Tellez, Manuel |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male medicine.medical_specialty Colorectal cancer Disease Biology carcinoma Bioinformatics SOX2 SDG 3 - Good Health and Well-being Cancer stem cell Internal medicine medicine Carcinoma Biomarkers Tumor Cluster Analysis Humans Stage (cooking) Aged Proportional Hazards Models colorectal Tissue microarray Proportional hazards model biomarkers Middle Aged medicine.disease Prognosis Immunohistochemistry Tissue Array Analysis cancer stem-cell immunohistochemistry Neoplastic Stem Cells Female Clinical Research Paper Colorectal Neoplasms |
| Zdroj: | Ong, C W, Chong, P Y, McArt, D G, Chan, J Y, Tan, H T, Kumar, A P, Chung, M C M, Clément, M-V, Soong, R, Van Schaeybroeck, S, Waugh, D J J, Johnston, P G, Dunne, P D & Salto-Tellez, M 2015, ' The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers ', Oncotarget, vol. 6, no. 14, pp. 12763-73 . < http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=3497 > Oncotarget |
| Popis: | Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western world. It is becoming increasingly clear that CRC is a diverse disease, as exemplified by the identification of subgroups of CRC tumours that are driven by distinct biology. Recently, a number of studies have begun to define panels of diagnostically relevant markers to align patients into individual subgroups in an attempt to give information on prognosis and treatment response. We examined the immunohistochemical expression profile of 18 markers, each representing a putative role in cancer development, in 493 primary colorectal carcinomas using tissue microarrays. Through unsupervised clustering in stage II cancers, we identified two cluster groups that are broadly defined by inflammatory or immune-related factors (CD3, CD8, COX-2 and FOXP3) and stem-like factors (CD44, LGR5, SOX2, OCT4). The expression of the stem-like group markers was associated with a significantly worse prognosis compared to cases with lower expression. In addition, patients classified in the stem-like subgroup displayed a trend towards a benefit from adjuvant treatment. The biologically relevant and poor prognostic stem-like group could also be identified in early stage I cancers, suggesting a potential opportunity for the identification of aggressive tumors at a very early stage of the disease. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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