Histopathological study of arthritic lesions induced by immunization with type II collagen in Lewis rats
| Autor: | Azusa Okaniwa, Hiromi Hinoue, Isao Takata, Tadashi Sato, Makoto Ueno, Yoshio Minato, Masakazu Takeshita, Kazunori Imaizumi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
musculoskeletal diseases
Pathology medicine.medical_specialty Erythema Injections Intradermal Type II collagen General Biochemistry Genetics and Molecular Biology medicine Ankylosis Animals Intradermal injection General Veterinary business.industry Cartilage Arthritis Granulation tissue General Medicine medicine.disease Hindlimb Rats medicine.anatomical_structure Rats Inbred Lew Rheumatoid arthritis Animal Science and Zoology Histopathology Female Joints Collagen medicine.symptom business |
| Zdroj: | Jikken dobutsu. Experimental animals. 43(1) |
| ISSN: | 0007-5124 |
| Popis: | Eight male DBA/1J mice immunized twice by intradermal injection of type II collagen were autopsied 12 weeks after the first immunization and analyzed for anti-type II collagen antibody level, and the limb joints were examined radiologically and histopathologically. Clinical onset of swelling and erythema in the limb joints occurred about 5 weeks after the first immunization and deformity of the limbs was observed in a few animals about 5 weeks later. Although there were marked individual differences, serum anti-type II collagen antibody levels were elevated in all animals. Histopathologically, the changes were similar to those seen in human rheumatoid arthritis and were characterized by proliferation of synovial lining cells, formation of granulation tissue with destruction of cartilage and subchondral bone, and ankylosis. Systematic examination of various joints of the fore- and hind-limbs revealed definitely that the sequence of arthritic lesions was not uniform. The knee joint was involved most frequently, but smaller joints such as the phalangeal joints were involved less frequently but exhibited severe changes. The significance of histopathological examinations in the evaluation of effects of anti-rheumatic drugs was discussed with reference to this model. |
| Databáze: | OpenAIRE |
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