Clinically-oriented monitoring of acute effects of methylphenidate on cerebral hemodynamics in ADHD children using fNIRS
| Autor: | Masako Nagashima, Takanori Yamagata, Mariko Y. Momoi, Yukifumi Monden, Ippeita Dan, Masako Okamoto, Eiju Watanabe, Haruka Dan, Yasushi Kyutoku |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Prefrontal Cortex Hemodynamics Neuropsychological Tests Audiology Impulsivity Cognition Physiology (medical) mental disorders medicine Humans Attention deficit hyperactivity disorder Attention Effects of sleep deprivation on cognitive performance Child Response inhibition Spectroscopy Near-Infrared Methylphenidate Functional Neuroimaging medicine.disease Sensory Systems Neurology Frontal lobe Attention Deficit Disorder with Hyperactivity Cerebral hemodynamics Cerebrovascular Circulation Central Nervous System Stimulants Female Neurology (clinical) medicine.symptom Psychology human activities Neuroscience medicine.drug |
| Zdroj: | Clinical Neurophysiology. 123:1147-1157 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2011.10.006 |
| Popis: | Objective Attention Deficit Hyperactivity Disorder (ADHD), a common developmental syndrome with inattention, hyperactivity, and impulsivity, is typically treated with the psychostimulant drug, methylphenidate (MPH). We explored the feasibility of using functional near-infrared spectroscopy (fNIRS) to search for a clinically implementable biological marker for the acute MPH effect on ADHD children. Methods Following an MPH washout period, twelve ADHD children performed a go/no-go task before and 1.5 h after MPH intake. fNIRS was used to monitor the lateral prefrontal cortical hemodynamics of ADHD children performing a go/no-go task. Results There was no significant activation in the lateral prefrontal cortices examined before MPH intake. However, after MPH intake, significant MPH-elicited activation (oxygenated hemoglobin signal increase) was detected in the right lateral prefrontal cortex (LPFC) implicated with response inhibition functions. There was a large significant correlation between increases in task performance and activation in the right LPFC. Conclusions The improved cognitive performance was associated with activation in the right LPFC, which might serve as a biological marker to monitor the effect of MPH in ADHD children. Significance MPH-effect assessment in ADHD children using fNIRS can be performed within a 3 h stay at a hospital during a single visit, and thus may be integrated into clinical practice. |
| Databáze: | OpenAIRE |
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