Integrated molecular, clinical, and ontological analysis identifies overlooked disease relationships
| Autor: | Gregory L. Gaskin, Timothy E. Sweeney, Erika Bongen, Nigam H. Shah, Liu C, Francesco Vallania, Paul J. Utz, Shane Lofgren, Rohit Vashisht, Winston A. Haynes, Purvesh Khatri |
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| Rok vydání: | 2017 |
| Předmět: |
0303 health sciences
business.industry Disease mechanisms Disease Research opportunities Computational biology medicine.disease 3. Good health Transcriptome 03 medical and health sciences 0302 clinical medicine Human disease medicine Transcriptome Profiles business 030217 neurology & neurosurgery Myositis 030304 developmental biology |
| DOI: | 10.1101/214833 |
| Popis: | Existing knowledge of human disease relationships is incomplete. To establish a comprehensive understanding of disease, we integrated transcriptome profiles of 41,000 human samples with clinical profiles of 2 million patients, across 89 diseases. Based on transcriptome data, autoimmune diseases clustered with their specific infectious triggers, and brain disorders clustered by disease class. Clinical profiles clustered diseases according to the similarity of their initial manifestation and later complications, identifying disease relationships absent in prior co-occurrence analyses. Our integrated analysis of transcriptome and clinical profiles identified overlooked, therapeutically actionable disease relationships, such as between myositis and interstitial cystitis. Our improved understanding of disease relationships will identify disease mechanisms, offer novel therapeutic targets, and create synergistic research opportunities. |
| Databáze: | OpenAIRE |
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