Lower arterial glucose concentrations in lambs with aortopulmonary shunts after an 18-hour fast
| Autor: | Gertie C. M. Beaufort-Krol, Gioia B. Smid, Janny Takens, Willem G. Zijlstra, Jaap R. G. Kuipers, Marieke C. Molenkamp |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Groningen University Institute for Drug Exploration (GUIDE) |
| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
Heart Bypass Left medicine.medical_specialty Heart disease Endocrinology Diabetes and Metabolism METABOLISM Carbohydrate metabolism Hypoglycemia Biology Endocrinology KETONE Internal medicine medicine Animals Heart Failure Carbon Isotopes Sheep BLOOD-FLOW Gluconeogenesis Hemodynamics Fasting Blood flow Metabolism medicine.disease Cori cycle Disease Models Animal CONSCIOUS LAMBS HEART RAT Glycolysis Hormone |
| Zdroj: | Metabolism, 48(9), 1082-1088. W B SAUNDERS CO-ELSEVIER INC |
| ISSN: | 0026-0495 |
| Popis: | Spontaneously occurring hypoglycemia has been described in children with severe acute congestive heart failure. Hypoglycemia may he the result of an increase in glucose utilization in tissues, a decrease in glucose production, or a decrease in the dietary intake of nutrients. To determine whether hypoglycemia may also occur in congenital heart disease with volume overloading, we investigated glucose metabolism during and after an 18-hour fast in nine lambs with an aortopulmonary left-to-right shunt and nine control lambs. Plasma levels of hormones involved in the endocrine control of glucose metabolism were determined. The glucose production rate (rate of appearance [R-a]) was studied using [U-C-13]glucose. Gluconeogenesis through the Cori cycle was estimated by measuring glucose C-13 recycling. The arterial glucose concentration (3,409 +/- 104 v 4,338 +/- 172 mu mol/L, P |
| Databáze: | OpenAIRE |
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