Decreased plasma levels of brain-derived neurotrophic factor (BDNF) during mixed episodes of bipolar disorder
| Autor: | Federica Vanelli, Davide Costanzo, Caterina Franceschini, Donatella Marazziti, Luciano Domenici, Armando Piccinni, Ilenia Moroni, Hagop S. Akiskal, Nicola Origlia, Antonello Veltri, Liliana Dell'Osso |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Enzyme-Linked Immunosorbent Assay Severity of Illness Index DSM-5 Neurotrophic factors Internal medicine mental disorders medicine Humans Bipolar disorder Major depressive episode Brain-derived neurotrophic factor Depressive Disorder Analysis of Variance Depressive Disorder Major Bipolar spectrum Brain-Derived Neurotrophic Factor Major BDNF Mixed state Biomarkers medicine.disease Psychiatry and Mental health Clinical Psychology Mood Endocrinology nervous system Mood disorders Female Psychiatry and Mental Health Biomarker (medicine) Antidepressant medicine.symptom Psychology Neuroscience |
| Zdroj: | Journal of Affective Disorders. 171:167-170 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2014.08.058 |
| Popis: | Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neurogenesis and neuroplasticity. Decreased blood levels of BDNF have been found during acute manic and depressive states. BDNF has been proposed as a biomarker in illness phases of mood disorders. No information is available regarding BDNF levels during the mixed states of bipolar disorder (BD). The aim of this study was to evaluate BDNF levels during mixed episodes of BD patients and compare them with those of healthy subjects and depressed patients.Plasma BDNF levels were measured by an ELISA assay in 18 patients with major depressive episode (MDE), 19 patients with mixed episode (ME) and 15 healthy subjects (HS).BDNF levels were significantly higher in HS, as compared with patients׳ samples (HS vs. MDE patients: p001; HS vs. ME patients: p=.022). No significant differences were found between BDNF levels of ME and MDE patients. The severity of illness as assessed by CGI-S was significantly higher in ME than in MDE patients (p=.01).The small sample size may have weakened the power of statistical analyses. All patients received mood-stabilizing and antidepressant treatments which have been reported to influence peripheral BDNF levels.Our results are consistent with previous studies showing reduced BDNF during both manic and depressive episodes. This finding supports the role of BDNF as a state-marker of mood episodes, and may represent a contribution to a unitary approach model between unipolar and BDs, as well as to the manic-depressive spectrum model. |
| Databáze: | OpenAIRE |
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