Do Breast Implants Adversely Affect Prognosis among Those Subsequently Diagnosed with Breast Cancer? Findings from an Extended Follow-Up of a Canadian Cohort
Autor: | Eric Lavigne, Howard Morrison, Jacques Brisson, Sai Yi Pan, Paul J. Villeneuve, Eric J. Holowaty, Lin Xie |
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Rok vydání: | 2012 |
Předmět: |
Adult
Oncology Canada medicine.medical_specialty Epidemiology Breast Implants Breast Neoplasms law.invention Cohort Studies Breast cancer law Internal medicine medicine Humans Stage (cooking) skin and connective tissue diseases Neoplasm Staging Proportional Hazards Models business.industry Mortality rate Cancer Prognosis medicine.disease Logistic Models Breast implant Cohort Population study Female Implant business Follow-Up Studies |
Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 21:1868-1876 |
ISSN: | 1538-7755 1055-9965 |
Popis: | Background: Cosmetic breast implants may impair the ability to detect breast cancers. The aims of this study were to examine whether implants and implant characteristics are associated with more advanced breast tumors at diagnosis and poorer survival. Methods: Study population includes all invasive breast cancer cases diagnosed during follow-up of the large Canadian Breast Implant Cohort. A total of 409 women with cosmetic breast implants and 444 women with other cosmetic surgery were diagnosed with breast cancer. These women were compared for stage at diagnosis using multinomial logistic regression models. Cox proportional hazards regression models were used for breast cancer-specific mortality analyses. Comparisons were also conducted according to implant characteristics. Results: Compared with women with other cosmetic surgery, those with cosmetic breast implants had at later stage breast cancer diagnosis (OR of having stage III/IV vs. stage I at diagnosis: 3.04, 95% confidence interval (CI): 1.81–5.10; P < 0.001). A nonstatistically significant increase in breast cancer-specific mortality rate for women with breast implants relative to surgical controls was observed (HR = 1.32, 95% CI: 0.94–1.83, P = 0.11). No statistically significant differences in stage and breast cancer mortality were observed according to implant characteristics. Conclusions: At diagnosis, breast cancers tended to be at more advanced stages among women with cosmetic breast implants. Breast cancer-specific survival was lower in these women although the reduction did not reach statistical significance. Impact: Further investigations of the effect of breast implants on breast cancer prognosis are warranted. Cancer Epidemiol Biomarkers Prev; 21(10); 1868–76. ©2012 AACR. |
Databáze: | OpenAIRE |
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