Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome
| Autor: | Roberto Romero, Adi L. Tarca, Nikolina Docheva, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Kenneth V. Honn, Zhonghui Xu, Juan Pedro Kusanovic, Senlin Zhou, Ricardo Gomez, Krishna Rao Maddipati |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Epoxygenase medicine.medical_specialty Amniotic fluid Inflammation QD415-436 urologic and male genital diseases Biochemistry Gastroenterology eicosanoids Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Internal medicine Lipidomics medicine Humans neoplasms Clinical chorioamnionitis 030219 obstetrics & reproductive medicine omega-3 fatty acids biology business.industry Fatty Acids Cell Biology Lipid signaling Lipidome Amniotic Fluid lipoxygenase female genital diseases and pregnancy complications Chorioamnionitis Cross-Sectional Studies 030104 developmental biology inflammation Metabolome biology.protein lipidomics Female intra-amniotic inflammation medicine.symptom Patient-Oriented and Epidemiological Research business |
| Zdroj: | Journal of Lipid Research, Vol 57, Iss 10, Pp 1906-1916 (2016) |
| ISSN: | 0022-2275 |
| Popis: | Clinical chorioamnionitis at term (TCC) is the most common obstetrical infliction diagnosed in labor and delivery units worldwide and is associated with a substantial increase in maternal and neonatal morbidity and mortality. This obstetrical complication is a heterogeneous condition, as only half of patients have detectable microorganisms in the amniotic cavity. Because bioactive lipids play a key role in the initiation and resolution of an inflammatory response, we aimed to characterize the amniotic fluid lipidome in patients with TCC. We studied the amniotic fluid of patients in the following groups: 1) spontaneous labor at term without clinical chorioamnionitis (TLB) and 2) spontaneous labor at term with clinical chorioamnionitis (TCC). The TCC group was subdivided into a) those with microbial invasion of the amniotic cavity (TCC-MIAC) and b) those without microbial invasion of the amniotic cavity (TCC-noMIAC). The amniotic fluid concentration of proinflammatory lipid mediators did not differ between patients in TLB with TCC. In contrast, concentration of lipids with anti-inflammatory/proresolution properties was significantly lower in all patients with TCC than in those with TLB. These results suggest that while proinflammatory lipid mediators are involved in infection-driven intra-amniotic inflammation, a relative deficiency of anti-inflammatory/proresolution lipid mediator biosynthesis is a characteristic of TCC. |
| Databáze: | OpenAIRE |
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