Coronary Heart Disease Risk Associated with Primary Isolated Hypertriglyceridemia; a Population‐Based Study
| Autor: | Carin Y. Smith, Seyedmohammad Saadatagah, Ahmed K. Pasha, Kent R. Bailey, Lubna Alhalabi, Medhat Farwati, Harigopal Sandhyavenu, Iftikhar J. Kullo, Christina M. Wood-Wentz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Minnesota hypertriglyceridemia Coronary Disease 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Cardiovascular Disease Epidemiology medicine Secondary Prevention Humans Diseases of the circulatory (Cardiovascular) system 030212 general & internal medicine coronary heart disease Triglycerides Retrospective Studies Original Research business.industry Incidence Hypertriglyceridemia Middle Aged medicine.disease Prognosis Coronary heart disease Population based study Primary Prevention Increased risk Concomitant Population Surveillance RC666-701 Female epidemiology Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 11 (2021) Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| DOI: | 10.1161/JAHA.120.019343 |
| Popis: | Background Hypertriglyceridemia is associated with increased risk of coronary heart disease but the association is often attributed to concomitant metabolic abnormalities. We investigated the epidemiology of primary isolated hypertriglyceridemia (PIH) and associated cardiovascular risk in a population‐based setting. Methods and Results We identified adults with at least one triglyceride level ≥500 mg/dL between 1998 and 2015 in Olmsted County, Minnesota. We also identified age‐ and sex‐matched controls with triglyceride levels P = 0.022). There was no statistically significant association between PIH and cerebrovascular disease (HR, 1.06; 95% CI, 0.65‐1.73, P = 0.813), peripheral artery disease (HR, 1.27; 95% CI, 0.43‐3.75; P = 0.668), or the composite end point of all 3 (HR, 1.28; 95% CI, 0.92‐1.80; P =0.148) in adjusted models. Conclusions PIH was associated with incident coronary heart disease events (although there was attenuation after adjustment for conventional risk factors), supporting a causal role for triglycerides in coronary heart disease. The condition is relatively prevalent but awareness and control are low. |
| Databáze: | OpenAIRE |
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