Development of Severe Thyroid-Associated Ophthalmopathy in a Patient with Disseminated Thyroid Cancer Treated with Recombinant Human Thyrotropin/Radioiodine and Retinoic Acid
| Autor: | Tommy Andersson, Lena Sjödell, Gertrud Berg, Ernst Nyström, Svante Jansson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Retinoic acid Thyrotropin Thyroglobulin Gastroenterology law.invention Papillary thyroid cancer Iodine Radioisotopes chemistry.chemical_compound Endocrinology law Internal medicine medicine Humans Thyroid Neoplasms Isotretinoin Thyroid cancer Thyroid-Associated Ophthalmopathy Aged biology business.industry Radioiodine therapy medicine.disease Recombinant Proteins Graves Ophthalmopathy chemistry Thyroidectomy Recombinant DNA biology.protein Female Antibody business |
| Zdroj: | Thyroid. 15:1389-1394 |
| ISSN: | 1557-9077 1050-7256 |
| DOI: | 10.1089/thy.2005.15.1389 |
| Popis: | We present a case in which a patient with disseminated well-differentiated papillary thyroid cancer developed severe thyroid-associated ophthalmopathy. Eight years after initial surgery and ablative radioiodine therapy the patient was found to have multiple pulmonary metastases. The metastases showed poor uptake of radioiodine. An attempt was made to use 13-cis-retinoic acid in order to achieve a redifferentiation of the thyroid cancer cells before recombinant human thyrotropin (rhTSH) stimulated radioiodine therapy. The treatment did not improve the uptake of radioiodine. However, approximately 2 weeks after completion of the treatment the patient experienced discomfort in her eyes and then over the next months she developed a severe ophthalmopathty. The analyses of TSH receptor antibodies and S-thyroglobulin simultaneously showed a pronounced increase. An association between therapy given and severe ophthalmopathy cannot be excluded. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|