Fibrillary glomerulonephritis in a human immunodeficiency virus-positive, hepatitis C-negative Indian patient: Expanding the profile of renal involvement in human immunodeficiency virus infection

Autor: Smita Mary Matthai, Priscilla Rupali, Anna B. Pulimood, Neelaveni Duhli, Anna T Valson, Santosh Varughese
Rok vydání: 2018
Předmět:
Microbiology (medical)
Male
Hepatitis C virus
Biopsy
030232 urology & nephrology
lcsh:QR1-502
030204 cardiovascular system & hematology
medicine.disease_cause
Kidney
lcsh:Microbiology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Glomerulonephritis
HIV associated immune complex mediated kidney disease
medicine
lcsh:Pathology
Fibrillary glomerulonephritis
HIV associated renal disease
Humans
AIDS-Associated Nephropathy
Diagnostic electron microscopy
medicine.diagnostic_test
business.industry
Fibrillary Glomerulonephritis
virus diseases
General Medicine
Hepatitis C
Middle Aged
medicine.disease
Human Immunodeficiency virus infection
Immune complex
Microscopy
Electron
medicine.anatomical_structure
HIV-associated nephropathy
Immunology
HIV associated nephropathy
Renal biopsy
business
lcsh:RB1-214
Zdroj: Indian Journal of Pathology and Microbiology, Vol 61, Iss 4, Pp 610-613 (2018)
ISSN: 0974-5130
Popis: Highly active anti retroviral therapy (HAART) has dramatically improved life expectancy of human immunodeficiency virus (HIV) infected patients, converting HIV infection into a chronic illness with associated changes in its attendant renal complications. The past two decades have witnessed a decrease in the prevalence of HIV associated nephropathy (HIVAN), traditionally considered to be the hall mark of renal involvement in HIV infection. Simultaneously a host of other glomerular and tubulo-interstitial diseases have emerged, expanding the spectrum of HIV associated renal diseases, predominant among which is HIV associated immune complex mediated kidney diseases (HIVICK). Of the diverse glomerular diseases constituting HIVICK, fibrillary glomerulonephritis (FGN) remains a rarity, with only two existing reports to date, confined to patients co-infected with Hepatitis C virus (HCV). The pathogenetic role of HIV in these patients remains under a cloud because of previously well established association of HCV infection and FGN. We report a case of FGN in a HIV seropositive, HCV negative Indian patient, highlighting the diagnostic electron microscopy (EM) findings of FGN and strengthening the causal association of HIV with FGN. In view of increasing heterogeneity of renal complications in HIV infection, the diagnostic utility of a comprehensive renal biopsy evaluation inclusive of EM is emphasized for appropriate selection of treatment modalities.
Databáze: OpenAIRE
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