A randomized controlled trial of intermittent compared with daily cotrimoxazole preventive therapy in HIV-infected children
| Autor: | Heather J, Zar, Lesley, Workman, Stanzi M, le Roux, Teresa, Jennings, Nomawethu, Jele, Hendrick Simon, Schaaf, Ann, Barclay-Loggie, Chris, Mulligan, David M, le Roux, Carl J, Lombard, Mark F, Cotton, E, Walters |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Immunology Population Zambia HIV Infections Rate ratio law.invention Anti-Infective Agents Randomized controlled trial law Antiretroviral Therapy Highly Active Internal medicine Trimethoprim Sulfamethoxazole Drug Combination Humans Immunology and Allergy Medicine heterocyclic compounds Prospective Studies education Adverse effect Antibacterial agent education.field_of_study Bacterial disease business.industry Hazard ratio Infant Surgery Hospitalization Infectious Diseases Tolerability Child Preschool HIV-1 Female business |
| Zdroj: | AIDS. 24:2225-2232 |
| ISSN: | 0269-9370 |
| Popis: | Objective: Cotrimoxazole preventive therapy (CPT) reduces morbidity and mortality in HIV-infected children. The WHO recommends prolonged daily CPT for HIV-infected infants and children. In adults, intermittent CPT has been associated with less adverse events than daily, with increased tolerability and equal efficacy. We investigated the efficacy and tolerability of intermittent CPT compared with daily CPT in HIV-infected children over a 5-year period. Design: A prospective randomized controlled study. Methods: HIV-infected children aged at least 8 weeks were randomized to thrice weekly or daily CPT. Outcome measures were mortality, bacterial infections, hospitalizations and adverse events. Results: Three hundred and twenty-four children (median age 23 months) were followed for 672 child-years; 165 (51 %) were randomized to intermittent CPT. Most children (287, 89%) were Centers for Disease Control and Prevention clinical category B or C; 207 (64%) received HAART during the study. Mortality (53 deaths, 16%) was similar in the intermittent CPT compared with the daily CPT group {24 (14%) vs. 29 (18%), hazard ratio 0.75 [95% confidence interval (CI) 0.44―1.29]}. The predominant causes of death in both groups were sepsis (17, 32%), pneumonia (13, 25%) or diarrhoea (8, 15%). Intermittent CPT was associated with more bacteraemias [incidence rate ratio 2.36 (95% CI 1.21-4.86)]. Children receiving intermittent CPT also spent more days in hospital [incidence rate ratio 1.15 (95% CI 1.04-1.28)]. The rate of serious adverse events was similar between groups [incidence rate ratio 1.07 (95% CI 0.58-2.02)]. Conclusion: Intermittent CPT was associated with more invasive bacterial disease than daily CPT, but survival was similar. Both regimens were well tolerated. On balance, daily CPT remains preferable to intermittent therapy for HIV-infected children. © 2010 Wolters Kluwer Health I Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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