Low levels of lead and glutathione markers of redox status in human blood

Autor: Caterina Vacchi-Suzzi, James Harrington, Laura Viens, Jaymie R. Meliker, Keith E. Levine, Roxanne Karimi
Rok vydání: 2017
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
Environmental Engineering
Population
New York
chemistry.chemical_element
010501 environmental sciences
medicine.disease_cause
01 natural sciences
Redox
Article
Cohort Studies
Dietary Exposure
Selenium
03 medical and health sciences
chemistry.chemical_compound
Geochemistry and Petrology
Internal medicine
Fatty Acids
Omega-3
medicine
Humans
Environmental Chemistry
education
0105 earth and related environmental sciences
General Environmental Science
Water Science and Technology
education.field_of_study
Human blood
medicine.diagnostic_test
Mercury
General Medicine
Glutathione
Middle Aged
Redox status
Oxidative Stress
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Lead
Seafood
chemistry
Biochemistry
Blood lead level
Oxidation-Reduction
Biomarkers
Oxidative stress
Zdroj: Environmental Geochemistry and Health. 40:1175-1185
ISSN: 1573-2983
0269-4042
DOI: 10.1007/s10653-017-0034-3
Popis: Exposure to lead (Pb) is implicated in a plethora of health threats in both adults and children. Increased exposure levels are associated with oxidative stress in the blood of workers exposed at occupational levels. However, it is not known whether lower Pb exposure levels are related to a shift toward a more oxidized state. To assess the association between blood lead level (BLL) and glutathione (GSH) redox biomarkers in a population of healthy adults, BLL and four GSH markers (GSH, GSSG, GSH/GSSG ratio and redox potential E(h)) were measured in the blood of a cross-sectional cohort of 282 avid seafood-eating healthy adults living on Long Island (NY). Additionally, blood levels of two other metals known to affect GSH redox status, selenium (Se) and mercury (Hg), and omega-3 index were tested for effect modification. Regression models were further adjusted for demographic and smoking status. Increasing exposure to Pb, measured in blood, was not associated with GSSG, but was associated with lower levels of GSH/GSSG ratio and more positive GSH redox potential E(h), driven by its association with GSH. No effect modification was observed in analyses stratified by Hg, Se, omega-3 index, sex, age, or smoking. Blood Pb is associated with lower levels of GSH and the GSH/GSSG ratio in this cross-sectional study of healthy adults.
Databáze: OpenAIRE
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