Control ofClostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils

Autor:	K. Schwarzer, Nathalie Nollet, Richard Ducatelle, F. Van Immerseel, Anouk Lanckriet, Leen Timbermont, Jeroen Dewulf, Freddy Haesebrouck
Přispěvatelé:	Pathology, Bacteriology and Avian Diseases, Universiteit Gent = Ghent University [Belgium] (UGENT), Pathology, Veterinary Public Health and Zoonoses, INVE Nutri-Ad
Rok vydání:	2010
Předmět:	Clostridium perfringens 040301 veterinary sciences Drug Compounding Biology medicine.disease_cause Cinnamaldehyde law.invention Microbiology 0403 veterinary science Butyric acid Necrosis chemistry.chemical_compound Food Animals law Oils Volatile medicine Animals Thymol Poultry Diseases Essential oil 2. Zero hunger General Immunology and Microbiology 0402 animal and dairy science Broiler Life Sciences 04 agricultural and veterinary sciences 040201 dairy & animal science Lauric acid Enteritis 3. Good health Disease Models Animal Eucalyptol chemistry Clostridium Infections Butyric Acid Animal Science and Zoology Chickens
Zdroj:	Avian Pathology Avian Pathology, Taylor & Francis, 2010, 39 (02), pp.117-121. ⟨10.1080/03079451003610586⟩
ISSN:	1465-3338 0307-9457
DOI:	10.1080/03079451003610586
Popis:	International audience; The efficacy of target released butyric acid, medium chain fatty acids (C6-C12 but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix, to control necrotic enteritis was investigated. The Minimal Inhibitory Concentrations of the different additives were determined in vitro, showing that lauric acid, thymol, and cinnamaldehyde are very effective in inhibiting the growth of C. perfringens. The in vivo effects were studied in an experimental necrotic enteritis model in broiler chickens. In a first in vivo trial, four groups of chickens were fed a diet supplemented with A) butyric acid, B) essential oils, C) butyric acid in combination with medium chain fatty acids or D) butyric acid in combination with medium chain fatty acids and essential oils. In all groups except for the group receiving only butyric acid, a significant decrease in the number of animals with necrotic lesions was found compared to the infected, untreated control group. In a second experiment the same products were tested but in a higher concentration. Additionally, a group fed a diet supplemented with only medium chain fatty acids was included. In all groups except for the group receiving butyric acid in combination with medium chain fatty acids and essential oils, a significant decrease in the number of animals with necrotic lesions was found compared to the infected, untreated control group. These results suggest that butyric acid, medium chain fatty acids and/or essential oils may contribute to the prevention of necrotic enteritis in broilers.
Databáze:	OpenAIRE
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