Renal Function in Unilateral Nephrectomy Subjects
| Autor: | John F. Mahony, Akos Z. Gyory, Pei-Ling Liu, Eileen D. M. Gallery, Roslyn Grigg |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Vasopressin medicine.medical_specialty Medullary cavity Urology medicine.medical_treatment Urinary system Renal function Kidney Kidney Function Tests Nephrectomy Excretion Humans Medicine Kidney transplantation Aged Aged 80 and over business.industry Middle Aged Unilateral nephrectomy medicine.disease Tissue Donors Surgery Proteinuria Female Kidney Diseases business Glomerular Filtration Rate |
| Zdroj: | Journal of Urology. 147:337-339 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(17)37230-0 |
| Popis: | Renal function in 32 subjects who had undergone unilateral nephrectomy (17 transplant donors and 15 subjects with unilateral renal disease) was compared with that of 22 normal subjects. The age-adjusted glomerular filtration rate was lower in transplant donors (79 +/- 15% of normal) than in those whose nephrectomy was performed for unilateral renal disease (90 +/- 12% of normal). The donors were also significantly older at nephrectomy (48 +/- 10 years versus 24 +/- 13 years, p less than 0.001). This finding may represent less capacity for compensatory hypertrophy. Proximal tubular and medullary function as assessed by 15-minute phenolsulfonphthalein excretion, maximum urinary concentration in response to water deprivation plus exogenous vasopressin, and urinary acidification in response to an oral acid load were all within normal limits for glomerular filtration rate. Overall renal function was well preserved after nephrectomy. A small number of patients did have increased cast excretion, which may signify the presence of mild renal disease in these subjects. |
| Databáze: | OpenAIRE |
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