Redox toxicology of environmental chemicals causing oxidative stress
Autor: | Yoshito Kumagai, Yumi Abiko, Fuli Zheng, Michael Aschner, Huangyuan Li, Filipe Marques Gonçalves |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
NF-E2-Related Factor 2 Articles from the Special Issue on Impact of environmental pollution and stress on redox signaling and oxidative stress pathways Edited by Thomas Münzel and Andreas Daiber Clinical Biochemistry chemistry.chemical_element medicine.disease_cause Biochemistry Redox Antioxidants NRF2 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Paraquat Metals Heavy Epigenetic modifications Redox signaling pathways medicine Humans Pesticides lcsh:QH301-705.5 Methylmercury Pollutant lcsh:R5-920 Cadmium Organic Chemistry respiratory system Pesticide Oxidative Stress 030104 developmental biology Heavy metals lcsh:Biology (General) chemistry Environmental chemistry Toxicity lcsh:Medicine (General) Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress Air pollutants |
Zdroj: | Redox Biology, Vol 34, Iss, Pp 101475-(2020) Redox Biology |
ISSN: | 2213-2317 |
Popis: | Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed. Graphical abstract Image 1 Highlights • Environmental chemicals cause redox toxicity via oxidative stress. • NRF2 acts as a sensor of oxidative stress and a positive regulator of antioxidants. • NRF2 responds to metals, pesticides and atmospheric pollutants. • NRF2 and related pathways can be epigenetically regulated. |
Databáze: | OpenAIRE |
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