Redox toxicology of environmental chemicals causing oxidative stress

Autor: Yoshito Kumagai, Yumi Abiko, Fuli Zheng, Michael Aschner, Huangyuan Li, Filipe Marques Gonçalves
Rok vydání: 2020
Předmět:
0301 basic medicine
NF-E2-Related Factor 2
Articles from the Special Issue on Impact of environmental pollution and stress on redox signaling and oxidative stress pathways
Edited by Thomas Münzel and Andreas Daiber
Clinical Biochemistry
chemistry.chemical_element
medicine.disease_cause
Biochemistry
Redox
Antioxidants
NRF2
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Paraquat
Metals
Heavy
Epigenetic modifications
Redox signaling pathways
medicine
Humans
Pesticides
lcsh:QH301-705.5
Methylmercury
Pollutant
lcsh:R5-920
Cadmium
Organic Chemistry
respiratory system
Pesticide
Oxidative Stress
030104 developmental biology
Heavy metals
lcsh:Biology (General)
chemistry
Environmental chemistry
Toxicity
lcsh:Medicine (General)
Oxidation-Reduction
030217 neurology & neurosurgery
Oxidative stress
Air pollutants
Zdroj: Redox Biology, Vol 34, Iss, Pp 101475-(2020)
Redox Biology
ISSN: 2213-2317
Popis: Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed.
Graphical abstract Image 1
Highlights • Environmental chemicals cause redox toxicity via oxidative stress. • NRF2 acts as a sensor of oxidative stress and a positive regulator of antioxidants. • NRF2 responds to metals, pesticides and atmospheric pollutants. • NRF2 and related pathways can be epigenetically regulated.
Databáze: OpenAIRE
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