Gestational and lactational exposure to low-dose bisphenol A increases Th17 cells in mice offspring

Autor: Qi-Xing Zhu, Changhao Wu, Tong Shen, Yingpei Li, Yun Li, Shimeng Luo, Jianhua Jiang
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
endocrine system
medicine.medical_specialty
Offspring
Health
Toxicology and Mutagenesis
Cellular differentiation
medicine.medical_treatment
Weaning
010501 environmental sciences
Biology
Toxicology
Interleukin-23
01 natural sciences
03 medical and health sciences
Immune system
Phenols
Pregnancy
RAR-related orphan receptor gamma
Internal medicine
medicine
Animals
Birth Weight
Lactation
Benzhydryl Compounds
0105 earth and related environmental sciences
Pharmacology
Mice
Inbred ICR
Dose-Response Relationship
Drug
Perinatal Exposure
Interleukin-6
Cell growth
Interleukins
Interleukin-17
General Medicine
Nuclear Receptor Subfamily 1
Group F
Member 3
030104 developmental biology
Endocrinology
Cytokine
Maternal Exposure
Prenatal Exposure Delayed Effects
Th17 Cells
Gestation
Female
Spleen
Zdroj: Environmental Toxicology and Pharmacology. 47:149-158
ISSN: 1382-6689
DOI: 10.1016/j.etap.2016.09.017
Popis: Increasing evidence demonstrates that perinatal exposure to Bisphenol A (BPA) can cause immune disorders throughout the life span. However, the biological basis for these immune disorders is poorly understood and the effects of exposure to BPA on Th17 development are unknown. The present study sought to characterize alterations of Th17 cells in childhood and adulthood following gestational and lactational exposure to environmentally relevant low-dose of BPA and the underlying mechanisms. Pregnant dams were exposed to BPA (10, 100 or 1000 nM) via drinking water from gestational day (GD) 0 to postnatal day (PND) 21. At PNDs 21 and 42, offspring mice were anesthetized, blood was obtained for cytokine assay and spleens were collected for Th17 cell frequency and RORγt mRNA expression analysis. Perinatal exposure to low-dose BPA resulted in a dose-dependent and gender-specific persistent rise in Th17 cells accompanied by an increase of RORγt mRNA expression in the offsprings. The contents of major Th17 cell-derived cytokines (IL-17 and IL-21) and those essential for Th17 cell differentiation (IL-6 and IL-23) were also increased compared to those in controls. These changes were more pronounced in female than in male offsprings. However, perinatal exposure to low-dose BPA had little effect on serum TGF-β, another key regulator for Th17 cell development. Our results suggest that gestational and lactational exposure to a low-dose of BPA can affect Th17 cell development via an action on its transcription factor and the regulatory cytokines. These findings provide novel insight into sustained immune disorders by BPA exposure during development.
Databáze: OpenAIRE
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